Adult onset Krabbe disease may mimic motor neurone disease
Henderson, R. D., MacMillan, J. C. and Bradfield, J. M. (2003) Adult onset Krabbe disease may mimic motor neurone disease. Journal of Clinical Neuroscience, 105: 638-639. doi:10.1016/S0967-5868(02)00302-8
Krabbe's disease (galactocerebrosidase deficiency) rarely presents in adults, usually with predominantly upper motor neurone clinical features. We report a case in whom the clinical features were similar to motor neurone disease. Nerve conduction studies and neuroimaging were important in leading to the correct diagnosis. Differences in adult-onset presentations are described. (C) 2003 Elsevier Science Ltd. All rights reserved.