T cell regulation of the immune response to infection in periodontal diseases

Yamazaki, K., Yoshie, H. and Seymour, G.J. (2003) T cell regulation of the immune response to infection in periodontal diseases. Histology And Histopathology, 18 3: 889-896.

Author Yamazaki, K.
Yoshie, H.
Seymour, G.J.
Title T cell regulation of the immune response to infection in periodontal diseases
Journal name Histology And Histopathology   Check publisher's open access policy
ISSN 0213-3911
Publication date 2003-07-01
Sub-type Critical review of research, literature review, critical commentary
Volume 18
Issue 3
Start page 889
End page 896
Total pages 8
Editor F. Hernandez
J.F. Madrid
Place of publication Murcia, Spain
Publisher F. Hernandez
Collection year 2003
Language eng
Subject C1
320899 Dentistry not elsewhere classified
730112 Oro-dental and disorders
Abstract Although T cells have been implicated in the pathogenesis and are considered to be central both in progression and control of the chronic inflammatory periodontal diseases, the precise contribution of T cells to the regulation of tissue destruction has not been fully elucidated. Current dogma suggests that immunity to infection is controlled by distinct T helper 1 (Th1) and T helper 2 (Th2) subsets of T cells classified on the basis of their cytokine profile. Further, a subset of T cells with immunosuppressive function and cytokine profile distinct from Th1 or Th2 has been described and designated as regulatory T cells. Although these regulatory T cells have been considered to maintain self-tolerance resulting in the suppression of auto-immune responses, recent data suggest that these cells may also play a role in preventing infection-induced immunopathology. In this review, the role of functional and regulatory T cells in chronic inflammatory periodontal diseases will be summarized. This should not only provide an insight into the relationship between the immune response to periodontopathic bacteria and disease but should also highlight areas of development for potentially new therapeutic modalities.
Keyword Cell Biology
Pathology
Periodontitis
Gingivitis
T Cell
Cytokine
Immunoregulation
Porphyromonas-gingivalis
Immunohistological Analysis
Selective Reduction
Autoimmune-disease
Lymphocyte Subsets
Antigen Receptor
Alpha-chain
Tissues
Expression
Mice
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Dentistry Publications
 
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Created: Wed, 15 Aug 2007, 05:19:46 EST