A genomewide survey of developmentally relevant genes in Ciona intestinalis - V. Genes for receptor tyrosine kinase pathway and Notch signaling pathway

Satou, Y., Sasakura, Y., Yamada, L., Imai, K. S., Satoh, N. and Degnan, B. (2003) A genomewide survey of developmentally relevant genes in Ciona intestinalis - V. Genes for receptor tyrosine kinase pathway and Notch signaling pathway. Development Genes And Evolution, 213 5-6: 254-263.


Author Satou, Y.
Sasakura, Y.
Yamada, L.
Imai, K. S.
Satoh, N.
Degnan, B.
Title A genomewide survey of developmentally relevant genes in Ciona intestinalis - V. Genes for receptor tyrosine kinase pathway and Notch signaling pathway
Journal name Development Genes And Evolution   Check publisher's open access policy
ISSN 0949-944X
Publication date 2003
Sub-type Article (original research)
DOI 10.1007/s00427-003-0317-9
Volume 213
Issue 5-6
Start page 254
End page 263
Total pages 10
Place of publication New York
Publisher Springer-Verlag
Collection year 2003
Language eng
Subject C1
270202 Genome Structure
770302 Living resources (incl. impacts of fishing on non-target species)
Abstract In the present survey, we identified most of the genes involved in the receptor tyrosine kinase (RTK), mitogen activated protein kinase (MAPK) and Notch signaling pathways in the draft genome sequence of Ciona intestinalis, a basal chordate. Compared to vertebrates, most of the genes found in the Ciona genome had fewer paralogues, although several genes including ephrin, Eph and fringe appeared to have multiplied or duplicated independently in the ascidian genome. In contrast, some genes including kit/flt, PDGF and Trk receptor tyrosine kinases were not found in the present survey, suggesting that these genes are innovations in the vertebrate lineage or lost in the ascidian lineage. The gene set identified in the present analysis provides an insight into genes for the RTK, MAPK and Notch signaling pathways in the ancient chordate genome and thereby how chordates evolved these signaling pathway.
Keyword Cell Biology
Evolutionary Biology
Developmental Biology
Basal Chordates
Ciona Intestinalis
Genomewide Survey
Notch Signaling Pathway
Receptor Tyrosine Kinase Pathway
Growth-factor Receptor
Halocynthia-roretzi
Expression
Family
Insights
Cloning
Insulin
Transcription
Cascades
Homologs
Q-Index Code C1

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 41 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 52 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Access Statistics: 63 Abstract Views  -  Detailed Statistics
Created: Tue, 14 Aug 2007, 19:10:46 EST