Movement through slits: cellular migration via the Slit family

Piper, Michael and Little, Melissa (2002) Movement through slits: cellular migration via the Slit family. BioEssays, 25 1: 32-38. doi:10.1002/bies.10199


Author Piper, Michael
Little, Melissa
Title Movement through slits: cellular migration via the Slit family
Journal name BioEssays   Check publisher's open access policy
ISSN 0265-9247
Publication date 2002
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/bies.10199
Volume 25
Issue 1
Start page 32
End page 38
Total pages 7
Place of publication Cambridge, England
Publisher Company of Biologists Ltd
Collection year 2002
Language eng
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
Abstract First isolated in the fly and now characterised in vertebrates, the Slit proteins have emerged as pivotal components controlling the guidance of axonal growth cones and the directional migration of neuronal precursors. As well as extensive expression during development of the central nervous system (CNS), the Slit proteins exhibit a striking array of expression sites in non-neuronal tissues, including the urogenital system, limb primordia and developing eye. Zebrafish Slit has been shown to mediate mesodermal migration during gastrulation, while Drosophila slit guides the migration of mesodermal cells during myogenesis. This suggests that the actions of these secreted molecules are not simply confined to the sphere of CNS development, but rather act in a more general fashion during development and throughout the lifetime of an organism. This review focuses on the non-neuronal activities of Slit proteins, highlighting a common role for the Slit family in cellular migration.
Keyword Biology
Repulsive Axon Guidance
Central-nervous-system
Olfactory-bulb Axons
Neuronal Migration
Drosophila-melanogaster
Vertebrate Slit
Arp2/3 Complex
Convergent Extension
Actin Polymerization
Expression Patterns
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 14 Aug 2007, 19:00:30 EST