Charting the course of ovarian development in vertebrates

Loffler, Kelly A. and Koopman, Peter (2002) Charting the course of ovarian development in vertebrates. International Journal of Developmental Biology, 46 4: 503-510.


Author(s) Loffler, Kelly A.
Koopman, Peter
Title Charting the course of ovarian development in vertebrates
Journal name International Journal of Developmental Biology
Publication date 2002
Sub-type Article
Volume number 46
Issue number 4
ISSN 0214-6282
Start page 503
End page 510
Total pages 8
Place of publication Spain
Publisher UBC Press
Collection year 2002
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
Abstract The decision of the embryonic gonad to differentiate as either a testis or an ovary is a critical step in vertebrate development. The molecular basis of this decision has been the focus of much study, particularly over the past decade. Here we contrast the knowledge of early gonadal development and the switch to testis differentiation with the lack of molecular understanding of ovarian development at early stages. We review current knowledge regarding mechanisms of ovarian morphogenesis and propose a model for the hierarchical control of development of the fetal ovary, incorporating the few genes already known to be important and several signals or factors that are hypothesised to exist in the early ovary.
Keyword(s) Developmental Biology
Sex Determination
Ovary
Gonadogenesis
Reproduction
Germ Cells
Primordial Germ-cells
Mammalian Sex Determination
Determining Region
Gap-junctions
Mouse Embryos
Sertoli Cells
Fig-alpha
Differentiation
Migration
Growth
 
Versions
Version Filter Type
Access Statistics: 19 Abstract Views  -  Detailed Statistics
Created: Tue, 14 Aug 2007, 18:57:27 EST  -  Detailed History