Immunity to asexual blood stage malaria and vaccine approaches

Wipasa, J., Elliott, S., Xu, H. and Good, M. F. (2002) Immunity to asexual blood stage malaria and vaccine approaches. Immunology And Cell Biology, 80 5: 401-414. doi:10.1046/j.1440-1711.2002.01107.x


Author Wipasa, J.
Elliott, S.
Xu, H.
Good, M. F.
Title Immunity to asexual blood stage malaria and vaccine approaches
Journal name Immunology And Cell Biology   Check publisher's open access policy
ISSN 0818-9641
Publication date 2002-10
Sub-type Article (original research)
DOI 10.1046/j.1440-1711.2002.01107.x
Open Access Status
Volume 80
Issue 5
Start page 401
End page 414
Total pages 14
Place of publication Australia
Publisher Blackwell Publishing Asia
Collection year 2002
Language eng
Subject C1
321206 Preventive Medicine
730213 Preventive medicine
1107 Immunology
Abstract The development of a malaria vaccine seems to be a definite possibility despite the fact that even individuals with a life time of endemic exposure do not develop sterile immunity. An effective malaria vaccine would be invaluable in preventing malaria-associated deaths in endemic areas, especially amongst children less than 5 years of age and pregnant women. This review discusses our current understanding of immunity against the asexual blood stage of malaria - the stage that is responsible for the symptoms of the disease - and approaches to the design of an asexual blood stage vaccine.
Keyword Cell Biology
Immunology
Asexual Blood Stage
Malaria
Vaccine
Merozoite Surface Protein-1
Tumor-necrosis-factor
Plasmodium-falciparum Malaria
Apical Membrane Antigen-1
Carboxyl-terminal Fragment
Delta-t-cells
Intercellular-adhesion Molecule-1
Experimental Cerebral Malaria
Naturally Acquired-immunity
Factor-like Domains
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 14 Aug 2007, 18:57:11 EST