Nature and specificity of the required protective immune response that develops postchallenge in mice vaccinated with the 19-kilodalton fragment of Plasmodium yoelii merozoite surface protein 1

Wipasa, Jiraprapa, Xu, Huji, Makobongo, Morris, Gatton, Michelle, Stowers, Anthony and Good, Michael F. (2002) Nature and specificity of the required protective immune response that develops postchallenge in mice vaccinated with the 19-kilodalton fragment of Plasmodium yoelii merozoite surface protein 1. Infection And Immunity, 70 11: 6013-6020. doi:10.1128/IAI.70.11.6013-6020.2002

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Author Wipasa, Jiraprapa
Xu, Huji
Makobongo, Morris
Gatton, Michelle
Stowers, Anthony
Good, Michael F.
Title Nature and specificity of the required protective immune response that develops postchallenge in mice vaccinated with the 19-kilodalton fragment of Plasmodium yoelii merozoite surface protein 1
Journal name Infection And Immunity
ISSN 1098-5522
1070-6313
Publication date 2002-11
Sub-type Article (original research)
DOI 10.1128/IAI.70.11.6013-6020.2002
Open Access Status File (Publisher version)
Volume 70
Issue 11
Start page 6013
End page 6020
Total pages 8
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2002
Language eng
Abstract Immunity induced by the 19-kDa fragment of Plasmodium yoelii merozoite surface protein 1 (MSP1(19)) is dependent on high titers of specific antibodies present at the time of challenge and a continuing active immune response postinfection. However, the specificity of the active immune response postinfection has not been defined. In particular, it is not known whether anti-MSP1(19) antibodies that arise following infection alone are sufficient for protection. We developed systems to investigate whether an MSP1(19)-specific antibody response alone both prechallenge and postchallenge is sufficient for protection. We were able to exclude antibodies with other specificities, as well as any contribution of MSP1(19)-specific CD4(+) T cells acting independent of antibody, and we concluded that an immune response focused solely on MSP1(19)-specific antibodies is sufficient for protection. The data imply that the ability of natural infection to boost an MSPI,g-specific antibody response should greatly improve vaccine efficacy.
Keyword Immunology
Infectious Diseases
Carboxyl-terminal Fragment
Cd4(+) T-cells
Malaria Infection
Rodent Malaria
Immunization
Msp1(19)
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 14 Aug 2007, 18:56:59 EST