MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells

Wykes, M., MacDonald, K.P.A., Tran, M., Quin, R.J., Xing, P.X., Gendler, S.J., Hart, D.N.J. and McGuckin, M.A. (2002) MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells. Journal of Leukocyte Biology, 72 4: 692-701.

Author Wykes, M.
MacDonald, K.P.A.
Tran, M.
Quin, R.J.
Xing, P.X.
Gendler, S.J.
Hart, D.N.J.
McGuckin, M.A.
Title MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells
Journal name Journal of Leukocyte Biology   Check publisher's open access policy
ISSN 0741-5400
Publication date 2002-09-01
Sub-type Article (original research)
Volume 72
Issue 4
Start page 692
End page 701
Total pages 10
Place of publication Bethesda, MD., U.S.A.
Publisher Federation of theAmerican Society of Experimental Biology
Collection year 2002
Language eng
Subject C1
320202 Cellular Immunology
730102 Immune system and allergy
Abstract The MUC1 mucin (CD227) is a cell surface mucin originally thought to be restricted to epithelial tissues. We report that CD227 is expressed on human blood dendritic cells (DC) and monocyte-derived DC following in vitro activation. Freshly isolated murine splenic DC had very low levels of CD227; however, all DC expressed CD227 following in vitro culture. In the mouse spleen, CD227 was seen on clusters within the red pulp and surrounding the marginal zone in the white pulp. Additionally, we confirm CD227 expression by activated human T cells and show for the first time that the CD227 cytoplasmic domain is tyrosine-phosphorylated in activated T cells and DC and is associated with other phosphoproteins, indicating a role in signaling. The function of CD227 on DC and T cells requires further elucidation.
Keyword Cell Biology
T Cell
Membrane-associated Mucin
Tyrosine Phosphorylation
Immune Regulation
Episialin Muc1
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
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Created: Tue, 14 Aug 2007, 18:55:48 EST