The E(NK) model: extending the NK model to incorporate gene-by-environment interactions and epistasis for diploid genomes

Cooper, Mark and Podlich, Dean W. (2002) The E(NK) model: extending the NK model to incorporate gene-by-environment interactions and epistasis for diploid genomes. Complexity, 7 6: 31-47. doi:10.1002/cplx.10044


Author Cooper, Mark
Podlich, Dean W.
Title The E(NK) model: extending the NK model to incorporate gene-by-environment interactions and epistasis for diploid genomes
Journal name Complexity   Check publisher's open access policy
ISSN 1099-0526
1076-2787
Publication date 2002-07
Sub-type Article (original research)
DOI 10.1002/cplx.10044
Volume 7
Issue 6
Start page 31
End page 47
Total pages 17
Place of publication New York, NY, U.S.A.
Publisher Wiley & Sons
Collection year 2002
Language eng
Subject C1
300203 Plant Improvement (Selection, Breeding and Genetic Engineering)
620100 Field Crops
Abstract The haploid NK model developed by Kauffman can be extended to diploid genomes and to incorporate gene-by-environment interaction effects in combination with epistasis. To provide the flexibility to include a wide range of forms of gene-by-environment interactions, a target population of environment types (TPE) is defined. The TPE consists of a set of E different environment types, each with their own frequency of occurrence. Each environment type conditions a different NK gene network structure or series of gene effects for a given network structure, providing the framework for defining gene-by-environment interactions. Thus, different NK models can be partially or completely nested within the E environment types of a TPE, giving rise to the E(NK) model for a biological system. With this model it is possible to examine how populations of genotypes evolve in context with properties of the environment that influence the contributions of genes to the fitness values of genotypes. We are using the E(NK) model to investigate how both epistasis and gene-by-environment interactions influence the genetic improvement of quantitative traits by plant breeding strategies applied to agricultural systems. © 2002 Wiley Periodicals, Inc.
Keyword NK model
diploid
gene-by-environment interaction
epistasis
plant breeding
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Agriculture and Food Sciences
 
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Created: Tue, 14 Aug 2007, 18:52:50 EST