Neuronal calcium-binding proteins and schizophrenia

Eyles, DW, McGrath, JJ and Reynolds, GP (2002) Neuronal calcium-binding proteins and schizophrenia. Schizophrenia Research, 57 1: 27-34. doi:10.1016/S0920-9964(01)00299-7


Author Eyles, DW
McGrath, JJ
Reynolds, GP
Title Neuronal calcium-binding proteins and schizophrenia
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1016/S0920-9964(01)00299-7
Volume 57
Issue 1
Start page 27
End page 34
Total pages 8
Place of publication Netherlands
Publisher Elsevier Science B.V.
Collection year 2002
Language eng
Subject C1
321021 Psychiatry
321204 Mental Health
730211 Mental health
Abstract Calcium-binding proteins (CBPs) such as calbindin, parvalbumin and calretinin are used as immunohistochemical markers for discrete neuronal subpopulations. They are particularly useful in identifying the various subpopulations of GABAergic interneurons that control output from prefrontal and cingulate cortices as well as from the hippocampus. The strategic role these interneurons play in regulating output from these three crucial brain regions has made them a focus for neuropathological investigation in schizophrenia. The number of pathological reports detailing subtle changes in these CBP-containing interneurons in patients with schizophrenia is rapidly growing. These proteins however are more than convenient neuronal markers. They confer survival advantages to neurons and can increase the neuron's ability to sustain firing. These properties may be important in the subtle pathophysiology of nondegenerative phenomena such as schizophrenia. The aim of this review is to introduce the reader to the functional properties of CBPs and to examine the emerging literature reporting alterations in these proteins in schizophrenia as well as draw some conclusions about the significance of these findings. (C) 2002 Elsevier Science B.V. All rights reserved.
Keyword Psychiatry
Schizophrenia
Calretinin
Calbindin
Parvalbumin
Calcium-binding Proteins
Neuropathology
Local Circuit Neurons
Prefrontal Cortex
Calbindin D-28k
Hippocampal-neurons
Immunoreactive Neurons
Cingulate Cortex
Cerebral-cortex
Axon Terminals
Cells
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Wed, 15 Aug 2007, 04:50:32 EST