Chloroquine or sulfadoxine-pyrimethamine for the treatment of uncomplicated, Plasmodium falciparum malaria during an epidemic in Central Java, Indonesia

Maguire, J. D., Lacy, M. D., Sururi,, Sismadi, P., Krisin,, Wiady, I., Laksana, B., Bangs, M. J., Masbar, S., Susanti, I., Basuki, W., Barcus, M. J., Marwoto, H., Edstein, M. D. and Tjokrosonto, S. (2002-10) Chloroquine or sulfadoxine-pyrimethamine for the treatment of uncomplicated, Plasmodium falciparum malaria during an epidemic in Central Java, Indonesia. Annals of Tropical Medicine & Parasitology, 96 7: 655-668.

Document type: Journal Article
Collection: Centre for Military and Veterans' Health Publications

Author(s) Maguire, J. D.
Lacy, M. D.
Sururi,
Sismadi, P.
Krisin,
Wiady, I.
Laksana, B.
Bangs, M. J.
Masbar, S.
Susanti, I.
Basuki, W.
Barcus, M. J.
Marwoto, H.
Edstein, M. D.
Tjokrosonto, S.
Title Chloroquine or sulfadoxine-pyrimethamine for the treatment of uncomplicated, Plasmodium falciparum malaria during an epidemic in Central Java, Indonesia
Journal name Annals of Tropical Medicine & Parasitology
Publication date 2002-10
Sub-type Article
Volume number 96
Issue number 7
ISBN 0003-4983
Start page 655
End page 668
Total pages 14
Editor(s) D. Molyneux
K. Wallbanks
Place of publication United Kingdom
Publisher Maney Publishing
Collection year 2002
Subject C1
321202 Epidemiology
730101 Infectious diseases
Abstract A recent malaria epidemic in the Menoreh Hills of Central Java has increased concern about the re-emergence of endemic malaria on Java, which threatens the island's 120 million residents. A 28-day, in-vivo test of the efficacy of treatment of malaria with antimalarial drugs was conducted among 16 7 villagers in the Menoreh Hills. The treatments investigated, chloroquine (CQ) and sulfadoxine pyrimethamine (SP), constitute, respectively, the first- and second-line treatments for uncomplicated malaria in Indonesia. The prevalence of malaria among 1389 residents screened prior to enrollment was 33%. Treatment outcomes were assessed by microscopical diagnoses, PCR-based confirmation of the diagnoses, measurement of the whole-blood concentrations of CQ and desethylchloroquine (DCQ), and identification of the Plasmodium falciparum genotypes. The 28-day cumulative incidences of therapeutic failure for CQ and SP were, respectively, 47% (N = 36) and 22% (N = 50) in the treatment of P. falciparum, and 18% (N = 77) and 67% (N = 6) in the treatment of P. vivax. Chloroquine was thus an ineffective therapy for P. falciparum malaria, and the presence of CQ-resistant P. vivax and SP-resistant P. falciparum will further compromise efforts to control resurgent malaria on Java.
Keyword(s) Public, Environmental & Occupational Health
Parasitology
Tropical Medicine
In-vivo
Irian-jaya
Resistance
Identification
Parasites
Diagnosis
Pcr
Additional Notes DOI: 10.1179/000349802125002310
 
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