Harmful drinking in military veterans with post-traumatic stress disorder: Association with the D2 dopamine receptor A1 allele

Young, R. M., Lawford, B. R., Noble, E. P., Kann, B., Wilkie, A., Ritchie, T., Arnold, L. and Shadforth, S (2002) Harmful drinking in military veterans with post-traumatic stress disorder: Association with the D2 dopamine receptor A1 allele. Alcohol And Alcoholism, 37 5: 451-456. doi:10.1093/alcalc/37.5.451


Author Young, R. M.
Lawford, B. R.
Noble, E. P.
Kann, B.
Wilkie, A.
Ritchie, T.
Arnold, L.
Shadforth, S
Title Harmful drinking in military veterans with post-traumatic stress disorder: Association with the D2 dopamine receptor A1 allele
Journal name Alcohol And Alcoholism   Check publisher's open access policy
ISSN 0735-0414
1464-3502
Publication date 2002
Sub-type Article (original research)
DOI 10.1093/alcalc/37.5.451
Open Access Status DOI
Volume 37
Issue 5
Start page 451
End page 456
Total pages 6
Place of publication Oxford
Publisher Oxford University Press
Collection year 2002
Language eng
Subject C1
321021 Psychiatry
730211 Mental health
1117 Public Health and Health Services
Abstract Aims: The frequency of the Taq I A alleles (A1 and A2) of the D2 dopamine receptor (DRD2) gene was examined in Caucasian post-traumatic stress disorder (PTSD) patients and controls. Results: In 91 PTSD patients, the frequency of the A1 allele was higher (P = 6.12 x 10(-3)) than in the 51 controls. In the 38 PTSD harmful drinkers (greater than or equal to60 g alcohol/day), A1 allelic frequency was higher (P = 3.91 x 10(-2)) than in the 53 non-harmful drinkers (<60 g alcohol/day), the former being also higher (P = 3.76 x 10(-4)) than in controls. However, there was no difference between non-harmful drinkers and controls. Based on DRD2 allelic association, the 35 PTSD patients with the A1(+) (A1A1, A1A2) allele consumed more than twice the daily amount of alcohol than the 56 patients with the A1(-) (A2A2) allele (P = 1.94 x 10(-3)). When the hourly rate of alcohol consumed was compared, A1(+) allelic patients consumed twice the rate of the A1(-) allelic patients (P < 10(-7)). Conclusion: The DRD2 A1 allele was associated with PTSD. However, this association was found only in the harmful drinkers. PTSD patients with the A1(+) allele consumed more alcohol than patients with the A1(-) allele. The importance of determining alcohol consumption in DRD2 association studies with PTSD is suggested.
Keyword Substance Abuse
Vietnam Veterans
Drd2 Gene
Taqi A1
Environmental Contributions
Individual-differences
Healthy-volunteers
Substance-abuse
Social Drinkers
Drug-dependence
Alcoholism
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 14 Aug 2007, 18:43:19 EST