Associations between human liver and kidney cadmium content and immunochemically detected CYP4A11 apoprotein

Baker, JR, Satarug, S, Urbenjapol, S, Edwards, RJ, Williams, DJ, Moore, MR and Reilly, PEB (2002) Associations between human liver and kidney cadmium content and immunochemically detected CYP4A11 apoprotein. Biochemical Pharmacology, 63 4: 693-696.


Author Baker, JR
Satarug, S
Urbenjapol, S
Edwards, RJ
Williams, DJ
Moore, MR
Reilly, PEB
Title Associations between human liver and kidney cadmium content and immunochemically detected CYP4A11 apoprotein
Journal name Biochemical Pharmacology   Check publisher's open access policy
ISSN 0006-2952
Publication date 2002
Sub-type Article (original research)
DOI 10.1016/S0006-2952(01)00905-4
Volume 63
Issue 4
Start page 693
End page 696
Total pages 4
Place of publication Oxford, England
Publisher Pergamon-Elsevier Science Ltd
Collection year 2002
Language eng
Subject C1
321299 Public Health and Health Services not elsewhere classified
730210 Environmental health
Abstract This present study was undertaken to assess potential effects of cadmium on CYP4A11 apoprotein in human liver and kidney as detected by Western blotting using a highly specific anti-peptide antibody. Liver and kidney cortex samples were autopsy specimens of 37 individuals (26 mates and I I females) whose ages ranged from 3 to 89 years. All were Caucasians who had not been exposed to cadmium in the workplace. Reduced CYP4A11 apoprotein levels were found in chronic hepatitis samples and in liver samples showing fatty changes. In contrast, increased CYP4A11 apoprotein levels were found in liver samples having higher cadmium content compared to the lower cadmium content samples. Increased CYP4A11 levels were also found in liver samples from female donors, compared to male donors; the difference being attributable to higher female liver cadmium burden. In distinction to liver, lowered CYP4A11 levels were seen in the kidney cortex samples which have high cadmium content, It is proposed here that the difference between the absolute cadmium burden of the liver and kidney samples may be responsible for the different patterns of expression of CYP4A11 in these two tissues. Further, since cadmium exposure may be associated with derangement in blood pressure control, it is interesting to note the possible relationship between altered CYP4A11-dependent production of arachidonic acid hydroxy and epoxy metabolites in kidney cortex and altered control of blood pressure. Our findings provide a possible link between these observations. (C) 2002 Elsevier Science Inc. All rights reserved.
Keyword Human Autopsy
Cadmium
Cytochrome P450
Fatty Acid
Vasoactive Metabolites
Blood Pressure
Hypertension
Cyp4f2
Acid
Pharmacology & Pharmacy
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
National Research Centre for Environmental Toxicology Publications
 
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