A lipid core peptide construct containing a conserved region determinant of the group a streptococcal M protein elicits heterologous opsonic antibodies

Olive, Colleen, Batzloff, Michael R., Horvath, Aniko, Wong, Allan, Clair, Timothy, Yarwood, Penny, Toth, Istvan and Good, Michael F. (2002) A lipid core peptide construct containing a conserved region determinant of the group a streptococcal M protein elicits heterologous opsonic antibodies. Infection And Immunity, 70 5: 2734-2738. doi:10.1128/IAI.70.5.2734-2738.2002

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Author Olive, Colleen
Batzloff, Michael R.
Horvath, Aniko
Wong, Allan
Clair, Timothy
Yarwood, Penny
Toth, Istvan
Good, Michael F.
Title A lipid core peptide construct containing a conserved region determinant of the group a streptococcal M protein elicits heterologous opsonic antibodies
Journal name Infection And Immunity
ISSN 1098-5522
1070-6313
Publication date 2002-05
Sub-type Article (original research)
DOI 10.1128/IAI.70.5.2734-2738.2002
Open Access Status File (Publisher version)
Volume 70
Issue 5
Start page 2734
End page 2738
Total pages 5
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2002
Language eng
Abstract The study reported here investigated the immunogenicity and protective potential of a lipid core peptide (LCP) construct containing a conserved region determinant of M protein, defined as peptide J8. Parenteral immunization of mice with LCP-J8 led to the induction of high-titer serum immunoglobulin G J18-specific antibodies when the construct was coadministered with complete Freund's adjuvant (CFA) or administered alone. LCP-J8 in CFA had significantly enhanced immunogenicity compared with the monomeric peptide J8 given in CFA. Moreover, LCP-J8/CFA and LCP-J8 antisera opsonized four different group A streptococcal (GAS) strains, and the antisera did not cross-react with human heart tissue proteins. These data indicate the potential of an LCP-based M protein conserved region GAS vaccine in the induction of broadly protective immune responses in the absence of a conventional adjuvant.
Keyword Immunology
Infectious Diseases
Group-a Streptococci
B-cell Epitopes
T-cell
Mucosal Colonization
Amino-acids
Vaccine
Responses
Immunogenicity
Immunization
Recombinant
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 14 Aug 2007, 18:24:22 EST