A lipophilic adjuvant carrier system for antigenic peptides

Horvath, Aniko, Olive, Colleen, Wong, Allan, Clair, Timothy, Yarwood, Penny, Good, Michael and Toth, Istvan (2001) A lipophilic adjuvant carrier system for antigenic peptides. Letters in Peptide Science, 8 3-5: 285-288.


Author Horvath, Aniko
Olive, Colleen
Wong, Allan
Clair, Timothy
Yarwood, Penny
Good, Michael
Toth, Istvan
Title A lipophilic adjuvant carrier system for antigenic peptides
Journal name Letters in Peptide Science   Check publisher's open access policy
ISSN 0929-5666
Publication date 2001-05
Sub-type Article (original research)
DOI 10.1007/BF02446530
Volume 8
Issue 3-5
Start page 285
End page 288
Total pages 4
Editor J. D. Wade
Place of publication Netherlands
Publisher Kluwer Academic
Collection year 2002
Language eng
Subject C1
250302 Biological and Medical Chemistry
780103 Chemical sciences
Abstract A lipoamino acid based synthetic peptide, (Lipid Core Peptide, LCP) derived from the conserved region of group A streptococci (GAS) was evaluated as potential candidate in a vaccine to prevent GAS-associated diseases, including rheumatic heart disease and post-streptococcal acute glomerulonephritis. Multiple copies of a peptide sequence from the bacterial surface M protein were incorporated into a lipid core and it was used to immunize mice with and without the application of adjuvant. The LCP construct had significantly enhanced immunogenicity compared with the monomeric peptide epitope. Furthermore, the peptides incorporated into the LCP system generated antibodies without the use of any conventional adjuvant.
Keyword group A streptococci
lipid core peptides (LCP)
lipoamino acid
multiple antigenic peptides
peptide delivery
solid-phase peptide synthesis
vaccination
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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