Axon navigation in the mammalian primary olfactory pathway: Where to next?

Key, B. and St John, J. (2002) Axon navigation in the mammalian primary olfactory pathway: Where to next?. Chemical Senses, 27 3: 245-260.


Author Key, B.
St John, J.
Title Axon navigation in the mammalian primary olfactory pathway: Where to next?
Journal name Chemical Senses   Check publisher's open access policy
ISSN 0379-864X
Publication date 2002
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1093/chemse/27.3.245
Volume 27
Issue 3
Start page 245
End page 260
Total pages 16
Editor B W Ache
Place of publication Oxford
Publisher Oxford University Press
Collection year 2002
Language eng
Subject C1
270502 Neurobiology
780108 Behavioural and cognitive sciences
Abstract The process of establishing long-range neuronal connections can be divided into at least three discrete steps. First, axons need to be stimulated to grow and this growth must be towards appropriate targets. Second, after arriving at their target, axons need to be directed to their topographically appropriate position and in some cases, such as in cortical structures, they must grow radially to reach the correct laminar layer Third, axons then arborize and form synaptic connections with only a defined subpopulation of potential post-synaptic partners. Attempts to understand these mechanisms in the visual system have been ongoing since pioneer studies in the 1940s highlighted the specificity of neuronal connections in the retino-tectal pathway. These classical systems-based approaches culminated in the 1990s with the discovery that Eph-ephrin repulsive interactions were involved in topographical mapping. In marked contrast, it was the cloning of the odorant receptor family that quickly led to a better understanding of axon targeting in the olfactory system. The last 10 years have seen the olfactory pathway rise in prominence as a model system for axon guidance. Once considered to be experimentally intractable, it is now providing a wealth of information on all aspects of axon guidance and targeting with implications not only for our understanding of these mechanisms in the olfactory system but also in other regions of the nervous system.
Keyword Behavioral Sciences
Food Science & Technology
Neurosciences
Physiology
Linked Kallmann-syndrome
Cell-adhesion Molecules
Extracellular-matrix
Ensheathing Cells
Gene-expression
Receptor Neurons
In-vitro
Glomerular Formation
Odorant Receptors
Neurite Outgrowth
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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