Expression of MUC1 splice variants in benign and malignant ovarian tumours

Obermair, A., Schmid, B. C., Packer, L. M., Leodolter, S., Birner, P., Ward, B. G., Crandon, A. J., McGuckin, M. A. and Zeillinger, R. (2002) Expression of MUC1 splice variants in benign and malignant ovarian tumours. International Journal of Cancer, 100 2: 166-171. doi:10.1002/ijc.10456

Author Obermair, A.
Schmid, B. C.
Packer, L. M.
Leodolter, S.
Birner, P.
Ward, B. G.
Crandon, A. J.
McGuckin, M. A.
Zeillinger, R.
Title Expression of MUC1 splice variants in benign and malignant ovarian tumours
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 0020-7136
Publication date 2002
Sub-type Article (original research)
DOI 10.1002/ijc.10456
Open Access Status
Volume 100
Issue 2
Start page 166
End page 171
Total pages 6
Editor H. zur Hausen
H. Bartsch et al.
Place of publication New York
Publisher Wiley-Liss
Collection year 2002
Language eng
Subject C1
730108 Cancer and related disorders
321015 Oncology and Carcinogenesis
Abstract MUC1 is expressed on the surface of ovarian cancer cells. Nine different splice variants of MUC1 have been described, but no study has reported on the expression of MUC1 iso-forms in human ovarian cancer. Our study compares patterns of expression of MUC1 splice variants of malignant and benign ovarian tumours. Ovarian tissue samples were taken from patients with benign ovarian tumours (n = 34) and from patients who had surgery for primary (n = 47) or recurrent (n = 8) ovarian cancer. RT-PCR for MUC1 splice variants A, B, C, D, X, Y, Z, REP and SEC was performed and their expression compared to clinical and histopathologic parameters. Variants A, D, X, Y and Z were more frequently expressed in malignant than in benign tumours. All primary ovarian cancer cases were positive for variant REP but negative for variant SEC. No significant association of the expression of MUC1 splice variants with the response to chemotherapy or patient survival could be demonstrated. Expression of MUC1 splice variants A, D, X, Y, Z and REP is associated with the presence of malignancy, whereas expression of MUC1/SEC is associated with the absence of malignancy. (C) 2002 Wiley-Liss, Inc.
Keyword Oncology
Alternative Splicing
Ovarian Cancer
Benign Tumour
Cancer Cell-lines
Epithelial Mucin
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Created: Tue, 14 Aug 2007, 18:10:29 EST