Extensive vascularization of developing mouse ovaries revealed by caveolin-1 expression

Bullejos, Monica, Bowles, Jo and Koopman, Peter (2002) Extensive vascularization of developing mouse ovaries revealed by caveolin-1 expression. Developmental Dynamics, 225 1: 95-99. doi:10.1002/dvdy.10128


Author Bullejos, Monica
Bowles, Jo
Koopman, Peter
Title Extensive vascularization of developing mouse ovaries revealed by caveolin-1 expression
Journal name Developmental Dynamics   Check publisher's open access policy
ISSN 1097-0177
1058-8388
Publication date 2002-09
Sub-type Article (original research)
DOI 10.1002/dvdy.10128
Volume 225
Issue 1
Start page 95
End page 99
Total pages 5
Place of publication New York, N.Y. U.S.A.
Publisher Wiley-Liss
Collection year 2002
Language eng
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
Abstract Expression screening for genes preferentially expressed in mouse fetal ovaries relative to testes identified Cav-1 as a candidate female-specific gene. Cav-1 encodes caveolin-1, a component of the cell membrane invaginations known as caveolae, which are involved in lipid regulation and signal transduction. In situ hybridization revealed high levels of Cav-1 mRNA in developing ovaries, compared with moderate or low levels in testes. Analysis of caveolin-1 protein distribution by immunofluorescence showed this difference to be due to the development of a dense and complex vascular network in the developing ovary. These observations point to a higher degree of differentiation and organization of the early stage mammalian ovary than previously suspected. (C) 2002 Wiley-Liss, Inc.
Keyword Anatomy & Morphology
Developmental Biology
Ovary
Vasculogenesis
Angiogenesis
Caveolin-1
In Situ Hybridization
Sex Determination
Gene-expression
Membrane
Sry
Cells
Hybridization
Protein
Testis
Mice
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 14 Aug 2007, 18:05:07 EST