Effects of intravenous injection of Clostridium perfringens type D epsilon toxin in calves

Uzal, F. A., Kelly, W. R., Morris, W. E. and Assis, R. A. (2002) Effects of intravenous injection of Clostridium perfringens type D epsilon toxin in calves. Journal of Comparative Pathology, 126 1: 71-75. doi:10.1053/jcpa.2001.0514

Author Uzal, F. A.
Kelly, W. R.
Morris, W. E.
Assis, R. A.
Title Effects of intravenous injection of Clostridium perfringens type D epsilon toxin in calves
Journal name Journal of Comparative Pathology   Check publisher's open access policy
ISSN 0021-9975
Publication date 2002-01
Sub-type Article (original research)
DOI 10.1053/jcpa.2001.0514
Open Access Status
Volume 126
Issue 1
Start page 71
End page 75
Total pages 5
Editor I.D. Aitken
D. Buxton
Place of publication London, United Kingdom
Publisher W.B. Saunders
Collection year 2002
Language eng
Subject C1
300507 Microbiology (excl. Virology)
780105 Biological sciences
Abstract In cattle, a neurological lesion similar to that produced in sheep and goats by Clostridium perfringens type D enterotoxaemia has been reported. However, no causal relationship has been established between this disease and the lesion in cattle. The effects of single and multiple intravenous injections of epsilon toxin in three calves aged 6 months were studied. A further calf was inoculated intravenously with saline solution and used as a control. Epsilon toxin invariably produced neurological signs within 2-60 min of the end of the injection process. Clinical signs consisted of loss of consciousness, recumbency, convulsions, paddling, opisthotonus, hyperaesthesia and dyspnoea. Gross changes consisted of severe acute pulmonary oedema, which was particularly marked in the interlobular septa. The histological lesions consisted of intra-alveolar and interstitial oedema of the lung and variable degrees of perivascular proteinaceous oedema in the internal capsule, thalamus and cerebellar white matter. No clinical or post-mortem changes were observed in the control calf. These results show that calves are susceptible to the intravenous injection of epsilon toxin, and that they can show at least some of the histological lesions produced in sheep and goats by this toxin. (C) 2002 Harcourt Publishers Ltd.
Keyword Pathology
Veterinary Sciences
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
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Citation counts: TR Web of Science Citation Count  Cited 32 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 14 Aug 2007, 18:04:27 EST