Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin

Shen, X. Y., Lam, P. K. S., Shaw, G. R. and Wickramasinghe, W. (2002) Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin. Toxicon, 40 10: 1499-1501. doi:10.1016/S0041-0101(02)00151-4


Author Shen, X. Y.
Lam, P. K. S.
Shaw, G. R.
Wickramasinghe, W.
Title Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 2002-10
Sub-type Article (original research)
DOI 10.1016/S0041-0101(02)00151-4
Volume 40
Issue 10
Start page 1499
End page 1501
Total pages 3
Place of publication Oxford, England
Publisher Elsevier Science
Collection year 2002
Language eng
Subject C1
321299 Public Health and Health Services not elsewhere classified
730210 Environmental health
1115 Pharmacology and Pharmaceutical Sciences
Abstract Cylindrospermopsin (CYN), a potent cyanobacterial hepatotoxin produced by Cylindrospermopsis raciborskii and other cyanobacteria, is regularly found in water supplies in many parts of the world, and has been associated with the intoxication of humans and livestock. In this study, Balb/c mice were injected via the intraperitoneal (IP) route with a single dose of 0.2 mg/kg CYN. Animals were sacrificed at 6, 12, 24, 48 and 72 It. DNA was isolated from the mouse livers, and examined for strand breakage by alkaline gel electrophoresis (pH 12). Significant DNA strand breakage was observed in the mouse liver exposed to CYN, suggesting that induction of DNA strand breakage is probably one of the key mechanisms for CYN genotoxicity. (C) 2002 Elsevier Science Ltd. All rights reserved.
Keyword Pharmacology & Pharmacy
Toxicology
Genotoxicity
Cylindrospermopsin
Dna Strand Breaks
Alkaline Gel Electrophoresis
Raciborskii Woloszynska
Umezakia Natans
Toxicity
Mice
Identification
Water
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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Created: Tue, 14 Aug 2007, 17:59:04 EST