Cadmium levels in the lung, liver, kidney cortex, and urine samples from Australians without occupational exposure to metals

Satarug, S, Baker, JR, Reilly, PEB, Moore, MR and Williams, DJ (2002) Cadmium levels in the lung, liver, kidney cortex, and urine samples from Australians without occupational exposure to metals. Archives of Environmental Health, 57 1: 69-77.

Author Satarug, S
Baker, JR
Reilly, PEB
Moore, MR
Williams, DJ
Title Cadmium levels in the lung, liver, kidney cortex, and urine samples from Australians without occupational exposure to metals
Journal name Archives of Environmental Health   Check publisher's open access policy
ISSN 0003-9896
Publication date 2002
Sub-type Article (original research)
Volume 57
Issue 1
Start page 69
End page 77
Total pages 9
Place of publication Washington, USA
Publisher Heldref Publications
Collection year 2002
Language eng
Subject C1
321299 Public Health and Health Services not elsewhere classified
730299 Public health not elsewhere classified
Abstract The authors undertook this study to assess levels of cadmium exposure in the general population. Samples of lung, liver, and kidney were obtained from 61 cadavers (43 males, 18 females; 2-89 yr of age, mean age = 38.5 yr) who died from accidental causes and who were subject to postmortem examinations at the John Tonge Centre for Forensic Sciences, Queensland Health Scientific Services, Brisbane, Australia, in 1997 and 1998. Samples of bladder urine were also obtained from 22 cadavers. Tissue and urine samples were analyzed for cadmium, zinc, and copper with inductively coupled plasm (ICP) mass spectrometry. The overall mean values for cadmium in the lung, liver, and kidney cortex samples were 0.13, 0.95, and 15.45 mug/gm wet tissue weight. The average renal cadmium level in subjects with high lung-cadmium levels (n = 13) was 6 mug/gm wet tissue weight higher than that of similarly aged subjects who had medium lung-cadmium levels (n = 30). In females, the average level of cadmium in the liver was 74% greater than in males, and the average liver cadmium in females with high lung-cadmium levels was 100% higher than in males in the same age range who had the same high lung-cadmium levels. Renal cadmium accumulation tended to be greater in females than in males who were in the same age range and who had similar lung-cadmium levels, a result that suggested that there was a higher absorption rate of cadmium in females. The mean value for a urinary cadmium excretion of 2.30 mug/gm creatinine was found in a subset of samples that had a mean age of 39 yr and a renal cortex cadmium concentration of 18.6 mug/gm wet tissue weight. Urinary cadmium excretion rates were correlated more strongly with lung and kidney cadmium content than with age or liver cadmium levels. The results suggest that urinary cadmium excretion may be increased in smokers and could provide some estimate of body cadmium burdens in future Australian epidemiological studies.
Keyword Environmental Sciences
Public, Environmental & Occupational Health
Cadmium Body Burden
Cigarette Smoke
Dietary Cadmium
Exposure Assessment
Human Autopsy
Metal Toxicity
Middle-aged Women
Metallothionein Levels
Background Exposure
Renal Dysfunction
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
National Research Centre for Environmental Toxicology Publications
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Created: Tue, 14 Aug 2007, 17:57:41 EST