Free radicals in alcoholic myopathy: Indices of damage and preventive studies

Preedy, Victor R., Adachi, Junko, Asano, Migiwa, Koll, Michael, Mantle, David, Niemela, Onni, Parkkila, Seppo, Paice, Alistair G., Peters, Timothy, Rajendram, Rajkumar, Seitz, Helmut, Ueno, Yasuhiro and Worrall, Simon (2002) Free radicals in alcoholic myopathy: Indices of damage and preventive studies. Free Radical Biology And Medicine, 32 8: 683-687. doi:10.1016/S0891-5849(01)00794-8

Author Preedy, Victor R.
Adachi, Junko
Asano, Migiwa
Koll, Michael
Mantle, David
Niemela, Onni
Parkkila, Seppo
Paice, Alistair G.
Peters, Timothy
Rajendram, Rajkumar
Seitz, Helmut
Ueno, Yasuhiro
Worrall, Simon
Title Free radicals in alcoholic myopathy: Indices of damage and preventive studies
Journal name Free Radical Biology And Medicine   Check publisher's open access policy
ISSN 0891-5849
Publication date 2002-04-15
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0891-5849(01)00794-8
Volume 32
Issue 8
Start page 683
End page 687
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Elsevier Science
Collection year 2002
Language eng
Subject C1
320307 Medical Biochemistry - Other
730118 Organs, diseases and abnormal conditions not elsewhere classified
Abstract Chronic alcoholic myopathy affects up to two-thirds of all alcohol misusers and is characterized by selective atrophy of Type If (glycolytic, fast-twitch, anaerobic) fibers. In contrast, the Type I fibers (oxidative, slow-twitch, aerobic) are relatively protected. Alcohol increases the concentration of cholesterol hydroperoxides and malondialdehyde-protein adducts, though protein-carbonyl concentration levels do not appear to be overtly increased and may actually decrease in some studies. In alcoholics, plasma concentrations of a-tocopherol may be reduced in myopathic patients. However, a-tocopherol supplementation has failed to prevent either the loss of skeletal muscle protein or the reductions in protein synthesis in alcohol-dosed animals. The evidence for increased oxidative stress in alcohol-exposed skeletal muscle is thus inconsistent. Further work into the role of ROS in alcoholic myopathy is clearly warranted. (C) 2002 Elsevier Science Inc.
Keyword Biochemistry & Molecular Biology
Endocrinology & Metabolism
Free Radicals
Reactive Oxygen Species
Cholesterol Hydroperoxides
Skeletal-muscle Proteins
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 14 Aug 2007, 17:52:27 EST