Rhythmic variations in pain, stiffness, and manual dexterity in hand osteoarthritis

Bellamy, N, Sothern, RB, Campbell, J and Buchanan, WW (2002) Rhythmic variations in pain, stiffness, and manual dexterity in hand osteoarthritis. Annals of The Rheumatic Diseases, 61 12: 1075-1080. doi:10.1136/ard.61.12.1075

Author Bellamy, N
Sothern, RB
Campbell, J
Buchanan, WW
Title Rhythmic variations in pain, stiffness, and manual dexterity in hand osteoarthritis
Journal name Annals of The Rheumatic Diseases   Check publisher's open access policy
ISSN 0003-4967
Publication date 2002
Sub-type Article (original research)
DOI 10.1136/ard.61.12.1075
Volume 61
Issue 12
Start page 1075
End page 1080
Total pages 6
Editor L. van de Putte
T. Bardin et al.
Place of publication London
Publisher British Medical Journal Publishing Group
Collection year 2002
Language eng
Subject C1
321028 Rheumatology and Arthritis
730306 Evaluation of health outcomes
Abstract Objective: To explore circadian variation in pain, stiffness, and manual dexterity inpatients with hand osteoarthritis (OA). Methods: Twenty one patients with hand OA, as defined by ACR criteria (17 women, four men, mean age 62.2 years, range 52-74 years) self rated pain and stiffness on separate 10 cm horizontal visual analogue scales and performed bead intubation coordinometry (BIC) six times each day (on waking up, at bedtime, and every four hours in between) for 10 consecutive days. Each series (using data with the trend removed if there was a significant trend) was analysed for circadian rhythmicity by a cosine. vector technique (single cosinor). With individual data expressed as the percentage of the mean, group rhythm characteristics at period 24 hours were summarised for each variable by population mean cosinor analysis. Results: Individual analyses identified significant circadian rhythms at pless than or equal to0.05 for pain (n=15/21), stiffness (n=16/20), and dexterity (n=18/21), and a significant circadian rhythm on a group basis was identified for pain (p=0.013), stiffness (p<0.001), and dexterity (p<0.001). Pain was least at 1610 and stiffness at 1618. Peak dexterity occurred in mid-afternoon at 1548 and occurred within the 95% confidence interval of least pain (1312-1800) and stiffness (1520-1732). Conclusions: Dexterity was influenced by the patient's level of pain or stiffness, which changed systematically throughout the day. Similar results have been previously reported in 14 patients with rheumatoid arthritis where peak dexterity occurred at 1544 and at 1528 in 14 age and sex matched healthy controls. The predictability of rhythmic variation in pain, stiffness, and dexterity has implications for scheduling activities of daily living and for timing antirheumatic drug treatment.
Keyword Rheumatology
Circadian Variation
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Created: Tue, 14 Aug 2007, 17:50:00 EST