Increase in prevalence of nosocomial non-Candida albicans candidaemia and the association of Candida krusei with fluconazole use

Hope, W., Morton, A. and Eisen, D.P. (2002) Increase in prevalence of nosocomial non-Candida albicans candidaemia and the association of Candida krusei with fluconazole use. Journal of Hospital Infection, 50 1: 56-65. doi:10.1053/jhin.2001.1131


Author Hope, W.
Morton, A.
Eisen, D.P.
Title Increase in prevalence of nosocomial non-Candida albicans candidaemia and the association of Candida krusei with fluconazole use
Journal name Journal of Hospital Infection   Check publisher's open access policy
ISSN 0195-6701
1532-2939
Publication date 2002-01
Sub-type Article (original research)
DOI 10.1053/jhin.2001.1131
Volume 50
Issue 1
Start page 56
End page 65
Total pages 10
Editor S. P. Barrett
R. A. Barnes
et al.
Place of publication London, England
Publisher WB Saunders
Collection year 2002
Language eng
Subject C1
320401 Medical Bacteriology
730101 Infectious diseases
Abstract Candida is an important nosocomial pathogen. This study was undertaken to provide information on the rate of candidaemia, to define the risks for candidaemia and to describe and account for the epidemiology of candidaemia at our institution between 1992 and 1999. The overall rate was 0.052 per 1000 patient days and 0.27 per 1000 discharges. The major risks for candidaemia were colonization at a non-sterile site (OR 3.85, 95%CI 1.80-9.09), total parenteral nutrition (TPN) in the absence of neutropenia (OR 11.8, 95%CI 4.5-35.4, P<0.001) and neutropenia in the absence of TPN (OR 3.7, 95%CI 1.8-7.7, P<0.001). There was no change in the overall incidence of candidaemia but there was a steady decline in the rate of C. albicans with a corresponding rise in the incidence of non-C. albicans species. C. krusei was highly associated with fluconazole exposure (chi(2) =20.78, P<0.001). There eras no evidence of spread of C. krusei using random amplification of polymorphic DNA, suggesting the appearance of this organism was due to the selection pressure exerted by fluconazole. (C) 2001 The Hospital Infection Society.
Keyword Infectious Diseases
Candidaemia
Candida Krusei
Candida Albicans
Fluconazole
Rapd
Bone-marrow Transplantation
Hospital-acquired Candidemia
Intensive-care Unit
Fungal-infections
Cancer-patients
Hematologic Malignancies
Parapsilosis Fungemia
Parenteral-nutrition
Controlled Trial
Risk-factors
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Tue, 14 Aug 2007, 17:33:51 EST