Proposed modifications to metabolic model for glycogen-accumulating organisms under anaerobic conditions

Zeng, R., Yuan, Z., van Loosdrecht, M. C. M. and Keller, J. (2002) Proposed modifications to metabolic model for glycogen-accumulating organisms under anaerobic conditions. Biotechnology And Bioengineering, 80 3: 277-279. doi:10.1002/bit.10370


Author Zeng, R.
Yuan, Z.
van Loosdrecht, M. C. M.
Keller, J.
Title Proposed modifications to metabolic model for glycogen-accumulating organisms under anaerobic conditions
Journal name Biotechnology And Bioengineering   Check publisher's open access policy
ISSN 0006-3592
Publication date 2002
Sub-type Article (original research)
DOI 10.1002/bit.10370
Volume 80
Issue 3
Start page 277
End page 279
Total pages 3
Place of publication USA
Publisher John Wiley & Sons Inc
Collection year 2002
Language eng
Subject C1
Abstract Filipe et al. (2001) proposed an anaerobic metabolic model for glycogen-accumulating organisms (GAO) in which the succinate-propionate pathway was used to describe the production of propionyl-CoA. However, propionyl-CoA is only an intermediate product in the above pathway. Stopping at propionyl-CoA instead of propionate (the end product of the pathway) results in the consumption of one ATP from succinate to succinyl-CoA, which was not accounted for in the model of Filipe et al. (2001). This resulted in significant errors in the stoichiometric coefficients in the final metabolic model. A modified model is presented in this communication and is shown to fit the experimental data significantly better than the original model. (C) 2002 Wiley Periodicals, Inc.
Keyword Glycogen Accumulating Organisms (gao)
Metabolic Model
Succinate-propionate Pathway
Atp
Biotechnology & Applied Microbiology
Acetate Uptake
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Advanced Water Management Centre Publications
 
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Created: Tue, 14 Aug 2007, 17:15:27 EST