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A cluster of melioidosis cases from an endemic region is clonal and is linked to the water supply using molecular typing of Burkholderia pseudomallei isolates
Currie, B. J., Mayo, M., Anstey, N. M., Donohoe, P., Haase, A. and Kemp, D. J. (2001) A cluster of melioidosis cases from an endemic region is clonal and is linked to the water supply using molecular typing of Burkholderia pseudomallei isolates. American Journal of Tropical Medicine And Hygiene, 65 3: 177-179.
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| Author(s) |
Currie, B. J.
Mayo, M.
Anstey, N. M.
Donohoe, P.
Haase, A.
Kemp, D. J.
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| Title |
A cluster of melioidosis cases from an endemic region is clonal and is linked to the water supply using molecular typing of Burkholderia pseudomallei isolates
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| Journal name |
American Journal of Tropical Medicine And Hygiene
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| Publication date |
2001
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| Volume number |
65
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| Issue number |
3
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| ISSN |
0002-9637
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| Start page |
177
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| End page |
179
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| Total pages |
3
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| Place of publication |
Baltimore MD
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| Publisher |
Williams and Wilkins
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| Collection year |
2001
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| Language |
eng
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| Subject |
C1
320401 Medical Bacteriology
730101 Infectious diseases
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| Abstract |
Nine cases of melioidosis with four deaths occurred over a 28-month period in members of a small remote Aboriginal community in the top end of the Northern Territory of Australia. Typing by pulsed-field gel electrophoresis showed isolates of Burkholderia pseudomallei from six of the cases to be clonal and also identical to an isolate from the community water supply, but not to soil isolates. The clonality of the isolates found in this cluster contrasts with the marked genetic diversity of human and environmental isolates found in this region which is hyperendemic for B. pseudomallei. It is possible that the clonal bacteria persisted and were propagated in biofilm in the water supply system. While the exact mode of transmission to humans and the reasons for cessation of the outbreak remain uncertain, contamination of the unchlorinated community water supply is a likely explanation.
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| Keyword(s) |
Public, Environmental & Occupational Health
Tropical Medicine
Pseudomonas-pseudomallei
Australia
Thailand
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