A critical appraisal of the intrinsic pancreatic angiotensin-generating system

Sernia, Conrad (2001) A critical appraisal of the intrinsic pancreatic angiotensin-generating system. Journal of the Pancreas, 2 1: 50-55.


Author Sernia, Conrad
Title A critical appraisal of the intrinsic pancreatic angiotensin-generating system
Journal name Journal of the Pancreas   Check publisher's open access policy
ISSN 1590-8577
Publication date 2001-01
Sub-type Article (original research)
Volume 2
Issue 1
Start page 50
End page 55
Total pages 6
Editor Raffaele Pezzilli
Generoso Uomo
Place of publication Italy
Publisher ES Burioni Ricerche Bibliografiche
Collection year 2001
Language eng
Subject C1
1101 Medical Biochemistry and Metabolomics
11 Medical and Health Sciences
Abstract The pancreas is a relative newcomer to the stable of tissues with an intrinsic angiotensin-generating system. The involvement of this system in pancreatic activity will be dependent on the angiotensin-generating paths present in the pancreas and their precise cellular location. Thus far, renin, angiotensin-converting enzyme (ACE), angiotensin II and AT1 and AT2 receptors have been found. These are components of the "classical" renin-angiotensin system. But there is uncertainty as to their location and site of action. Furthermore, it is not known which, if any, alternative enzymes to renin and ACE are present, which angiotensins in addition to angiotensin II are generated and whether or not there are receptors to angiotensin IV and angiotensin-(1-7). Future research should focus on these aspects in order to provide a mechanistic basis to pancreatic physiological functions and to pathological conditions of clinical relevance.
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Tue, 14 Aug 2007, 16:58:25 EST