Signals from Eph and ephrin proteins: a developmental tool kit

Boyd, Andrew W. and Lackmann, Martin (2001) Signals from Eph and ephrin proteins: a developmental tool kit. Science's STKE, 112: re20. doi:10.1126/stke.2001.112.re20

Author Boyd, Andrew W.
Lackmann, Martin
Title Signals from Eph and ephrin proteins: a developmental tool kit
Journal name Science's STKE   Check publisher's open access policy
ISSN 1525-8882
Publication date 2001-12
Sub-type Article (original research)
DOI 10.1126/stke.2001.112.re20
Issue 112
Start page re20
Total pages 2
Editor Nancy R. Gough
L. Bryan Ray
Place of publication USA
Publisher Highwire Press
Collection year 2001
Language eng
Subject C1
321015 Oncology and Carcinogenesis
730108 Cancer and related disorders
Abstract Interactions between Eph receptors and their ligands the ephrin proteins are critically important in many key developmental processes. Emerging evidence also supports a role for these molecules in postembryonic tissues, particularly in pathological processes, including tissue injury and tumor metastasis. We review the signaling mechanisms that allow the 14 Eph and nine ephrin proteins to deliver intracellular signals that regulate cell shape and movement. What emerges is that the initiation of these signals is critically dependent on which Eph and ephrin proteins are expressed, the level of their expression, and, in some cases, which splice variants are expressed. Diversity at the level of initial interaction and in the downstream signaling processes regulated by Eph-ephrin signaling provides a subtle, versatile system of regulation of intercellular adhesion, cell shape, and cell motility.
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Tue, 14 Aug 2007, 16:55:01 EST