Post-antibiotic growth suppression of linezolid against Gram-positive bacteria

Munckhof, W. J., Giles, C. and Turnidge, J. D. (2001) Post-antibiotic growth suppression of linezolid against Gram-positive bacteria. Journal of Antimicrobial Chemotherapy, 47 6: 879-883. doi:10.1093/jac/47.6.879

Author Munckhof, W. J.
Giles, C.
Turnidge, J. D.
Title Post-antibiotic growth suppression of linezolid against Gram-positive bacteria
Journal name Journal of Antimicrobial Chemotherapy   Check publisher's open access policy
ISSN 0305-7453
Publication date 2001-06
Sub-type Article (original research)
DOI 10.1093/jac/47.6.879
Volume 47
Issue 6
Start page 879
End page 883
Total pages 5
Place of publication England, UK
Publisher Academic press
Collection year 2001
Language eng
Subject C1
320401 Medical Bacteriology
730101 Infectious diseases
Abstract The in vitro post-antibiotic effects (PAEs) of eight different concentrations of linezolid against Gram-positive cocci were investigated and the results analysed using the sigmoid E-max model for mathematically modelling the PAE. Mean maximal linezolid PAEs against strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Enterococcus faecium and Streptococcus pneumoniae were 2.2, 1.8, 2.8, 2.0 and 3.0 h, respectively. Resistance to methicillin (for the staphylococci), vancomycin (for the enterococci) and penicillin (for the pneumococci) had no effect on the duration of the PAE. Results of PAE testing support twice-daily dosing of linezolid in humans.
Keyword Infectious Diseases
Pharmacology & Pharmacy
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Tue, 14 Aug 2007, 16:51:55 EST