MUC1: Antibodies and immunoassays

Rye, Phil D. and McGuckin, Michael A. (2001) MUC1: Antibodies and immunoassays. Tumor Biology, 22 4: 269-272. doi:10.1159/000050626

Author Rye, Phil D.
McGuckin, Michael A.
Title MUC1: Antibodies and immunoassays
Journal name Tumor Biology   Check publisher's open access policy
ISSN 1010-4283
Publication date 2001
Sub-type Editorial
DOI 10.1159/000050626
Volume 22
Issue 4
Start page 269
End page 272
Total pages 4
Place of publication Basel, Switzerland
Publisher Karger
Collection year 2001
Language eng
Subject C1
320305 Medical Biochemistry - Proteins and Peptides
730199 Clinical health not specific to particular organs, diseases and conditions
Abstract High molecular weight mucins represent a unique challenge as tumor markers by virtue of their complex array of epitopes, The list is dominated by the high molecular weight mucins MUC1, CEA and CA125. While the currently accepted role for these tumor markers is in the prediction and detection of relapse, it is possible that their sensitivity and specificity can be improved. Although immunoassays detecting the tumor marker MUC1 are both sensitive and specific for predicting relapse in breast cancer, so far they are not in widespread use in the follow-up of this disease. Are there new combinations of conventional reagents that could improve assay sensitivity, or should we be looking for more radical changes in assay design incorporating combinatorial technology? Copyright (C) 2001 S. Karger AG, Basel.
Keyword Oncology
Tumor Markers
Immune Response
Thomsen-friedenreich Antigen
30 Monoclonal-antibodies
Q-Index Code C1

Document type: Journal Article
Sub-type: Editorial
Collection: School of Biomedical Sciences Publications
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Created: Tue, 14 Aug 2007, 16:51:35 EST