The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family

Clark, G. J., Cooper, B., Fitzpatrick, S., Green, B. and Hart, D. N. J. (2001) The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family. Tissue Antigens, 57 5: 415-423. doi:10.1034/j.1399-0039.2001.057005415.x


Author Clark, G. J.
Cooper, B.
Fitzpatrick, S.
Green, B.
Hart, D. N. J.
Title The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family
Journal name Tissue Antigens   Check publisher's open access policy
ISSN 0001-2815
1399-0039
Publication date 2001-05
Sub-type Article (original research)
DOI 10.1034/j.1399-0039.2001.057005415.x
Volume 57
Issue 5
Start page 415
End page 423
Total pages 9
Place of publication Copenhagen, Denmark
Publisher Blackwell Munksgaard
Collection year 2001
Language eng
Subject C1
320202 Cellular Immunology
730102 Immune system and allergy
Abstract The immunoregulatory signaling (IRS) family includes several molecules, which play major roles in the regulation of the immune response. The CMRF-35A and CMRF-35H molecules are two new members of the IRS family of molecules, that are found on a wide variety of haemopoietic lineages. The extracellular functional interactions of these molecules is presently unknown, although CMRF-35H on initiate an inhibitory signal and is internalized when cross-linked. In this paper, we described the gene structure for the CMRF-35A gene and its localization to human chromosome 17. The gene consists of four exons spanning approximately 4.5 kb. Exon 1 encodes the 5' untranslated region and leader sequence, exon 2 encodes the immunoglobulin (Ig)-like domain, exon 3 encodes the membrane proximal region and exon 4 encodes the transmembrane region, the cytoplasmic tail and the 3' untranslated region. A region in the 5' flanking sequence of the CMRF-35A gene, that promoted expression of a reporter gene was identified. The genes for the CMRF-35A and CMRF-35H molecules are closely linked on chromosome 17. Similarity between the Ig-like exons and the preceding intron of the two genes suggests exon duplication was involved in their evolution. We also identified a further member of the CMRF-35 family, the CMRF-35J pseudogene. This gene appears to have arisen by gene duplication of the CMRF-35A gene. These three loci-the CMRF-35A, CMRF-35J and CMRF-35H genes-form a new complex of IRS genes on chromosome 17.
Keyword Cell Biology
Immunology
Pathology
Cmrf-35
Gene Structure
Ig Superfamily
Leucocyte Receptors
Cell Inhibitory Receptor
Immunoglobulin-like Receptors
Genomic Organization
Nk Cells
Superfamily
Cloning
Complex
Promoter
Transcription
Phosphatases
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Tue, 14 Aug 2007, 16:51:21 EST