Broadsheet - Dendritic cells and their emerging clinical applications

Hart, DNJ (2001) Broadsheet - Dendritic cells and their emerging clinical applications. Pathology, 33 4: 479-492. doi:10.1080/00313020120083205


Author Hart, DNJ
Title Broadsheet - Dendritic cells and their emerging clinical applications
Journal name Pathology   Check publisher's open access policy
ISSN 0031-3025
Publication date 2001
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1080/00313020120083205
Volume 33
Issue 4
Start page 479
End page 492
Total pages 14
Place of publication England
Publisher Carfax
Collection year 2001
Language eng
Subject C1
320202 Cellular Immunology
730102 Immune system and allergy
Abstract Dendritic cells (DC) are now recognised as a unique leukocyte type, consisting of two or more subsets. The origins and functional inter-relationships of these cells are the subject of intense basic scientific investigation. They play important roles in initiating and directing immune responses, defending the host from pathogens and maintaining self tolerance. Fundamental studies are defining new molecules and mechanisms associated with DC function. The first methods for counting these rare blood cell populations are already providing interesting new clinical data. Indeed, abnormal DC function may contribute to deficiencies in the immune response against malignancies. Phase I trial data suggests that DC-based cancer vaccination protocols may contribute an important new biological approach to cancer therapy. Manipulation of DC to facilitate allogeneic transplantation and even to manage autoimmune disease are likely developments.
Keyword Pathology
Dendritic Cells
Cancer
Immunotherapy
Tolerance
Transplantation
Colony-stimulating Factor
Prostate-cancer Vaccine
Human Peripheral-blood
Chronic Myelogenous Leukemia
Antigen-presenting Cells
Necrosis-factor-alpha
Human Bone-marrow
In-vivo
Langerhans Cells
T-cells
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Mater Research Institute-UQ (MRI-UQ)
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 14 Aug 2007, 16:51:01 EST