Two new classes of conopeptides inhibit the alpha 1-adrenoceptor and noradrenaline transporter

Sharpe, I. A., Gehrmann, J., Loughnan, M. L., Thomas, L., Adams, D. A., Atkins, A., Palant, E., Craik, D. J., Adams, D. J., Alewood, P. F. and Lewis, R. J. (2001) Two new classes of conopeptides inhibit the alpha 1-adrenoceptor and noradrenaline transporter. Nature Neuroscience, 4 9: 902-907. doi:10.1038/nn0901-902


Author Sharpe, I. A.
Gehrmann, J.
Loughnan, M. L.
Thomas, L.
Adams, D. A.
Atkins, A.
Palant, E.
Craik, D. J.
Adams, D. J.
Alewood, P. F.
Lewis, R. J.
Title Two new classes of conopeptides inhibit the alpha 1-adrenoceptor and noradrenaline transporter
Journal name Nature Neuroscience   Check publisher's open access policy
ISSN 1097-6256
Publication date 2001
Sub-type Article (original research)
DOI 10.1038/nn0901-902
Volume 4
Issue 9
Start page 902
End page 907
Total pages 6
Editor Charles Jennings
Place of publication New York
Publisher Nature America Inc
Collection year 2001
Language eng
Subject C1
320700 Neurosciences
730000 - Health
Abstract Cone snails use venom containing a cocktail of peptides ('conopeptides') to capture their prey. Many of these peptides also target mammalian receptors, often with exquisite selectivity. Here we report the discovery of two new classes of conopeptides. One class targets alpha (1)-adrenoceptors (rho -TIA from the fish-hunting Conus tulipa), and the second class targets the neuronal noradrenaline transporter (chi -MrIA and chi -MrIB from the mollusk-hunting C. marmoreus). rho -TIA and chi -MrIA selectively modulate these important membrane-bound proteins. Both peptides act as reversible non-competitive inhibitors and provide alternative avenues for the identification of inhibitor drugs.
Keyword Neurosciences
Nicotinic Acetylcholine-receptor
1.1 Angstrom Resolution
Conus-geographus Venom
Alpha-conotoxin
Crystal-structure
Sodium-channels
Vas-deferens
Norepinephrine Transporter
Peptide
Antagonist
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Tue, 14 Aug 2007, 16:50:29 EST