Towards a blood-stage vaccine for malaria: Are we following all the leads?

Good, Michael F. (2001) Towards a blood-stage vaccine for malaria: Are we following all the leads?. Nature Reviews Immunology, 1 2: 117-125. doi:10.1038/35100540


Author Good, Michael F.
Title Towards a blood-stage vaccine for malaria: Are we following all the leads?
Journal name Nature Reviews Immunology   Check publisher's open access policy
ISSN 1471-1733
Publication date 2001-11
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/35100540
Volume 1
Issue 2
Start page 117
End page 125
Total pages 9
Place of publication England
Publisher Nature Publishing Group
Collection year 2001
Language eng
Subject CX
320200 Immunology
730102 Immune system and allergy
Abstract Although the malaria parasite was discovered more than 120 years ago, it is only during the past 20 years, following the cloning of malaria genes, that we have been able to think rationally about vaccine design and development. Effective vaccines for malaria could interrupt the life cycle of the parasite at different stages in the human host or in the mosquito. The purpose of this review is to outline the challenges we face in developing a vaccine that will limit growth of the parasite during the stage within red blood cells - the stage responsible for all the symptoms and pathology of malaria. More than 15 vaccine trials have either been completed or are in progress, and many more are planned. Success in current trials could lead to a vaccine capable of saving more than 2 million lives per year.
Keyword Immunology
Merozoite Surface Protein-1
Human-immunodeficiency-virus
Plasmodium-falciparum Malaria
Carboxyl-terminal Fragment
Apical Membrane Antigen-1
Chabaudi-adami Malaria
Chondroitin Sulfate-a
T-cell Epitope
Protective Immunity
Infected Erythrocytes
Q-Index Code CX

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Tue, 14 Aug 2007, 16:49:38 EST