TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma

Rae, Fiona K., Hooper, John D., Eyre, Helen J., Sutherland, Grant R., Nicol, David L. and Clements, Judith A. (2001) TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma. Genomics, 77 3: 200-207. doi:10.1006/geno.2001.6629


Author Rae, Fiona K.
Hooper, John D.
Eyre, Helen J.
Sutherland, Grant R.
Nicol, David L.
Clements, Judith A.
Title TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma
Journal name Genomics   Check publisher's open access policy
ISSN 0888-7543
1089-8646
Publication date 2001-08-15
Sub-type Article (original research)
DOI 10.1006/geno.2001.6629
Volume 77
Issue 3
Start page 200
End page 207
Total pages 8
Place of publication San Diego, Calif. USA
Publisher Academic Press
Collection year 2001
Language eng
Subject C1
321099 Clinical Sciences not elsewhere classified
730108 Cancer and related disorders
Abstract Using differential display PCR, we identified a novel gene upregulated in renal cell carcinoma. Characterization of the full-length cDNA and gene revealed that the encoded protein is a human homologue of the Drosophila melanogaster Tweety protein, and so we have termed the novel protein TTYH2. The orthologous mouse cDNA was also identified and the predicted mouse protein is 81% identical to the human protein. The encoded human TTYH2 protein is 534 amino acids and, like the other members of the tweety-related protein family, is a putative cell surface protein with five transmembrane regions. TTYH2 is located at 17q24; it is expressed most highly in brain and testis and at lower levels in heart, ovary, spleen, and peripheral blood leukocytes. Expression of this gene is upregulated in 13 of 16 (81%) renal cell carcinoma samples examined. In addition to a putative role in brain and testis, the overexpression of TTYH2 in renal cell carcinoma suggests that it may have an important role in kidney tumorigenesis.
Keyword Biotechnology & Applied Microbiology
Genetics & Heredity
Ttyh2
Tweety
Renal Cell Carcinoma
Differential Display Polymerase Chain Reaction
17q24
Tumor-suppressor Gene
Differential Display
Chromosomal Imbalances
Down-regulation
Cancer
Region
Dna
Identification
Expression
Receptor
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Tue, 14 Aug 2007, 16:43:34 EST