Immune responses to ISCOM (R) formulations in animal and primate models

Sjolander, A., Drane, D., Maraskovsky, E., Scheerlinck, J. P., Suhrbier, A., Tennent, J. and Pearse, M. (2001) Immune responses to ISCOM (R) formulations in animal and primate models. Vaccine, 19 17-19: 2661-2665. doi:10.1016/S0264-410X(00)00497-7


Author Sjolander, A.
Drane, D.
Maraskovsky, E.
Scheerlinck, J. P.
Suhrbier, A.
Tennent, J.
Pearse, M.
Title Immune responses to ISCOM (R) formulations in animal and primate models
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
Publication date 2001-03
Sub-type Article (original research)
DOI 10.1016/S0264-410X(00)00497-7
Volume 19
Issue 17-19
Start page 2661
End page 2665
Total pages 5
Editor R.E. Spier
K. Yamanishi
J. B. Campbell
Place of publication Oxford
Publisher Elsevier
Collection year 2001
Language eng
Subject C1
320299 Immunology not elsewhere classified
730102 Immune system and allergy
1103 Clinical Sciences
Abstract ISCOMs(R) are typically 40 nm cage-like structures comprising antigen, saponin, cholesterol and phospholipid. ISCOMs(R) have been shown to induce antibody responses and activate T helper cells and cyrolytic T lymphocytes in a number of animal species, including non-human primates. Recent clinical studies have demonstrated that ISCOMs(R) are also able to induce antibody and cellular immune responses in humans. This review describes the current understanding of the ability of ISCOMs(R) to induce immune responses and the mechanisms underlying this property. Recent progress in the characterisation and manufacture of ISCOMs(R) will also be discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.
Keyword Immunology
Medicine, Research & Experimental
Veterinary Sciences
Iscom (r)
Immune Responses
T Cell
Adjuvant Activity
Virus
Vaccine
Complexes
Macaques
Saponin
Protection
Correlate
Infection
Mucosal
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 14 Aug 2007, 16:43:24 EST