Early rise in blood pressure following administration of adrenocorticotropic hormone-[1-24] in humans

Jackson, RV, Nye, EJ, Grice, JE, Hockings, GI, Strakosch, CR, Walters, MM, Crosbie, GV, Torpy, DJ and Whitworth, JA (2001) Early rise in blood pressure following administration of adrenocorticotropic hormone-[1-24] in humans. Clinical And Experimental Pharmacology And Physiology, 28 9: 773-775. doi:10.1046/j.1440-1681.2001.03518.x


Author Jackson, RV
Nye, EJ
Grice, JE
Hockings, GI
Strakosch, CR
Walters, MM
Crosbie, GV
Torpy, DJ
Whitworth, JA
Title Early rise in blood pressure following administration of adrenocorticotropic hormone-[1-24] in humans
Journal name Clinical And Experimental Pharmacology And Physiology   Check publisher's open access policy
ISSN 0305-1870
Publication date 2001
Sub-type Article (original research)
DOI 10.1046/j.1440-1681.2001.03518.x
Volume 28
Issue 9
Start page 773
End page 775
Total pages 3
Place of publication Carlton, Australia
Publisher Blackwell Science Asia
Collection year 2001
Language eng
Subject C1
321004 Endocrinology
730105 Endocrine organs and diseases (incl. diabetes)
Abstract 1. An elevation in blood pressure has been consistently observed 24 h after adrenocorticotropic hormone (ACTH) administration and is caused by increased ACTH-stimulated cortisol secretion, in association with increased cardiac output. The aim of the present study was to investigate the previously undefined time of onset of this increase in blood pressure in normal humans. 2. Ten normal healthy volunteers received 250 mug ACTH-[1-24], in 500 mL normal saline, infused at a constant rate over 8 h. Six subjects also received a placebo infusion (normal saline only). Blood pressure, heart rate and cortisol levels were determined hourly. Adrenocorticotropic hormone (ACTH-[1-24] plus native ACTH) was measured at 0, 1, 7 and 8 h. 3. Infusion of ACTH-[1-24] produced maximal secretion rates of cortisol, resulting in a mean peak plasma level of 985 +/- 46 nmol/L at 8 h. In response, blood pressure and heart rate rose significantly by 2 h and remained generally elevated for the duration of the infusion. 4. The early onset of haemodynamic responses is consistent with classical steroid receptor-mediated genomic mechanisms, but could be due non-genomic mechanisms. 5. The cardiovascular consequences of therapeutic use of ACTH are well recognized. This results of the present study suggest that even diagnostic administration of ACTH, delivered over a few hours, may raise blood pressure.
Keyword Pharmacology & Pharmacy
Physiology
Blood Pressure
Corticotropin
Glucocorticoids
Induced Hypertension
Acth
Cortisol
Sheep
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 14 Aug 2007, 16:19:39 EST