Adult mouse intrinsic laryngeal muscles express high levels of the myogenic regulatory factor, MYF-5

Bain, N. L., Knight, M. A., ODonnell, L., Murdoch, B. E. and Trezise, A. E. O. (2001) Adult mouse intrinsic laryngeal muscles express high levels of the myogenic regulatory factor, MYF-5. Journal of Medical Speech-language Pathology, 9 3: 157-167.

Author Bain, N. L.
Knight, M. A.
ODonnell, L.
Murdoch, B. E.
Trezise, A. E. O.
Title Adult mouse intrinsic laryngeal muscles express high levels of the myogenic regulatory factor, MYF-5
Journal name Journal of Medical Speech-language Pathology   Check publisher's open access policy
Publication date 2001
Sub-type Article
Volume number 9
Issue number 3
ISSN 1065-1438
Start page 157
End page 167
Total pages 11
Editor B. Murdoch
Place of publication San Diego, CA
Publisher Singular
Collection year 2001
Language eng
Subject C1
321025 Rehabilitation and Therapy - Hearing and Speech
730303 Occupational, speech and physiotherapy
780105 Biological sciences
270205 Genetic Development (incl. Sex Determination)
Abstract The intrinsic laryngeal muscles display unique structural and functional characteristics that distinguish them from the skeletal muscle of the trunk and limbs. These features include relatively small muscle fibers, super-fast contraction speed, and fatigue resistance. The molecular basis of tissue-specific functions and other characteristics is differential gene expression. Accordingly, we have investigated the molecular basis of the functional specialization of the intrinsic laryngeal muscles by examining the expression of two key genes in the larynx, known to be important for skeletal muscle development and function: (a) the muscle regulatory factor, Myf-5, and (b) the superfast-contracting myosin heavy chain (EO-MyHC). We have found that the adult thyroarytenoid muscles express much higher levels of both Myf-5 and EO-MyHC messenger ribonucleic acid (mRNA), compared to lower hindlimb skeletal muscle where Myf-5 mRNA levels are very low and EO-MyHC is not detectable. These findings suggest that the unique functional characteristics of the intrinsic laryngeal muscles may be based in laryngeal muscle-specific gene expression directed by a unique combination of muscle regulatory factors. Such laryngeal muscle-specific genes may allow the future development of new treatments for laryngeal muscle dysfunction.
Keyword Clinical Neurology
Myosin Heavy-chain
Skeletal-muscle
Cystic-fibrosis
Cftr Expression
Gene Myf-5
Myod
Mice
Inactivation
Gradient
Lineage
Q-Index Code C1

Document type: Journal Article
Sub-type: Article
Collection: School of Health and Rehabilitation Sciences Publications
 
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Created: Tue, 14 Aug 2007, 16:11:10 EST