Does 'imprinting' with low prenatal vitamin D contribute to the risk of various adult disorders?

McGrath, J. J. (2001) Does 'imprinting' with low prenatal vitamin D contribute to the risk of various adult disorders?. Medical Hypothesis, 56 3: 367-371. doi:10.1054/mehy.2000.1226

Author McGrath, J. J.
Title Does 'imprinting' with low prenatal vitamin D contribute to the risk of various adult disorders?
Journal name Medical Hypothesis   Check publisher's open access policy
ISSN 0306-9877
Publication date 2001
Sub-type Article (original research)
DOI 10.1054/mehy.2000.1226
Volume 56
Issue 3
Start page 367
End page 371
Total pages 5
Place of publication UK
Publisher Harcourt Publishers Ltd
Collection year 2001
Language eng
Subject C1
321204 Mental Health
730211 Mental health
1103 Clinical Sciences
Abstract Hypovitaminosis D is a candidate risk-modifying factor for a diverse range of disorders apart from rickets and osteoporosis. Based on epidemiology, and on in vitro and animal experiment, vitamin D has been linked to multiple sclerosis, certain cancers (prostate, breast and colorectal), insulin-dependent diabetes mellitus and schizophrenia. I hypothesise that low pre- and perinatal vitamin D levels imprint on the functional characteristics of various tissues throughout the body, leaving the affected individual at increased risk of developing a range of adult-onset disorders. The hypothesis draws from recent advances in our understanding of the early origin of adult disease and proposes a 'critical window' during which vitamin D levels may have a persisting impact on adult health outcomes. Methods to test the hypothesis are outlined. If correct, the hypothesis has important implications for public health. Careful attention to maternal vitamin D status could translate into diverse improvements in health outcomes for the following generation. (C) 2001 Harcourt Publishers Ltd.
Keyword Medicine, Research & Experimental
Dependent Diabetes-mellitus
Kingdom-born Children
Colon Cancer
1,25-dihydroxyvitamin D-3
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Tue, 14 Aug 2007, 16:10:58 EST