A zebrafish homologue of deleted in colorectal cancer (zdcc) is expressed in the first neuronal clusters of the developing brain

Hjorth, J. T., Gad, J., Cooper, H. and Key, B. (2001) A zebrafish homologue of deleted in colorectal cancer (zdcc) is expressed in the first neuronal clusters of the developing brain. Mechanisms of Development, 109 1: 105-109. doi:10.1016/S0925-4773(01)00513-5


Author Hjorth, J. T.
Gad, J.
Cooper, H.
Key, B.
Title A zebrafish homologue of deleted in colorectal cancer (zdcc) is expressed in the first neuronal clusters of the developing brain
Journal name Mechanisms of Development   Check publisher's open access policy
ISSN 0925-4773
Publication date 2001
Sub-type Article (original research)
DOI 10.1016/S0925-4773(01)00513-5
Volume 109
Issue 1
Start page 105
End page 109
Total pages 5
Editor P. Gruss
H. Jackle
C. D. Stern
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Collection year 2001
Language eng
Subject C1
270502 Neurobiology
780108 Behavioural and cognitive sciences
17 Psychology and Cognitive Sciences
Abstract DCC (deleted in colon cancer), Neogenin and UNC-5 are all members of the immunoglobulin superfamily of transmembrane receptors which are believed to play a role in axon guidance by binding to their ligands, the Netrin/UNC-40 family of secreted molecules (Cell. Mol. Life Sci. 56 (1999) 62; Curr. Opin. Genet. Dev. 7 (1997) 87). Although zebrafish homologues of the Netrin family of secreted molecules have been reported, to date there has been no published description of zebrafish DCC homologues (Mol. Cell. Neurosci. 9 (1997) 293., Mol. Cell. Neurosci. I I ( 1998) 194; Mech. Dev. 62 (1997) 147). We report here the expression pattern of a zebrafish dcc (zdcc) homologue during the initial period of neurogenesis and axon tract formation within the developing central nervous system. Between 12 and 33 h post-fertilisation zdcc is expressed in a dynamic spatiotemporal pattern in all major subdivisions of the central nervous system. Double-labelling for zdcc and the post-mitotic neuronal marker HNK-1 revealed that subpopulations of neurons within the first nuclei of the zebrafish brain express zdcc. These results support our previous observation that patterning of neuronal clusters in the zebrafish brain occurs early in development (Dev. Bioi, 229 (2001) 271). (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
Keyword Axon Guidance
Dcc
Netrin
Zebrafish
Neural Development
Brain Patterning
Neurogenesis
Developmental Biology
Netrin-1a Expression
Embryonic Zebrafish
Axon Tracts
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Access Statistics: 77 Abstract Views  -  Detailed Statistics
Created: Tue, 14 Aug 2007, 16:03:37 EST