On surrogate methods for detecting lateral gene transfer

Ragan, Mark A. (2001) On surrogate methods for detecting lateral gene transfer. FEMS Microbiology Letters, 201 2: 187-191. doi:10.1111/j.1574-6968.2001.tb10755.x

Author Ragan, Mark A.
Title On surrogate methods for detecting lateral gene transfer
Journal name FEMS Microbiology Letters   Check publisher's open access policy
ISSN 0378-1097
Publication date 2001-07
Sub-type Article (original research)
DOI 10.1111/j.1574-6968.2001.tb10755.x
Volume 201
Issue 2
Start page 187
End page 191
Total pages 5
Place of publication Amsterdam, North Holland
Publisher Elsevier Science
Collection year 2001
Language eng
Subject C1
270306 Microbial Genetics
780105 Biological sciences
Abstract Surrogate methods for detecting lateral gene transfer are those that do not require inference of phylogenetic trees. Herein I apply four such methods to identify open reading frames (ORFs) in the genome of Escherichia coli K12 that may have arisen by lateral gene transfer. Only two of these methods detect the same ORFs more frequently than expected by chance, whereas several intersections contain many fewer ORFs than expected. Each of the four methods detects a different non-random set of ORFs. The methods may detect lateral ORFs of different relative ages; testing this hypothesis will require rigorous inference of trees. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science BN. All rights reserved.
Keyword Microbiology
Microbial Evolution
Lateral Gene Transfer
Horizontal Gene Transfer
Nucleotide Composition
Markov Models
Gc Content
Escherichia-coli Genome
Bacterial Genomes
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 129 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 129 times in Scopus Article | Citations
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Created: Tue, 14 Aug 2007, 16:01:48 EST