Growth hormone receptor and IGF-1 receptor immunoreactivity during orthodontic tooth movement in the prednisolone-treated rat

Ong, C. K. L., Joseph, B. K., Waters, M. J. and Symons, A. L. (2001) Growth hormone receptor and IGF-1 receptor immunoreactivity during orthodontic tooth movement in the prednisolone-treated rat. Angle Orthodontist, 71 6: 486-493.

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Author Ong, C. K. L.
Joseph, B. K.
Waters, M. J.
Symons, A. L.
Title Growth hormone receptor and IGF-1 receptor immunoreactivity during orthodontic tooth movement in the prednisolone-treated rat
Journal name Angle Orthodontist   Check publisher's open access policy
ISSN 0003-3219
1945-7103
Publication date 2001
Year available 2001
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 71
Issue 6
Start page 486
End page 493
Total pages 8
Editor David Turpin
Place of publication Edina, MN United States
Publisher Angle Orthodontists Research & Education Foundation
Collection year 2001
Language eng
Subject C1
320804 Dental Therapy
730112 Oro-dental and disorders
Abstract Bone remodeling during tooth movement is regulated by local and systemic factors. Two regulators of bone metabolism are growth hormone (GH) and insulin-like growth factor-I (IGF-1). Their effects are mediated via binding to GH receptor (GHR) and IGF-I receptor (IGF-IR) in target tissues. Corticosteroids may affect the activity of these growth factors. This study examined the effect of prednisolone on GHR and IGF-IR expression in dental tissues following orthodontic tooth movement. The corti ticosteroid-treated group (N = 6) was administered prednisolone ( 1 mg/kg,) daily and the control group (N = 6) received equivalent volumes of saline. An orthodontic force (30 g) was applied to the maxillary first molar. Animals were sacrificed 12 days postappliance insertion. Sagittal sections of the first molar were stained for GHR and IGF-IR immunoreactivity. GHR and IGF-IR cell counts were elevated following appliance-treatment. Orthodontic tooth movement appeared to up-regulate GHR and IGF-IR immunoreactivity, but this up-regulation was reduced following prednisolone treatment. The suppression of GHR and IGF-I immunoreactivity in steroid-treated animals infers the mechanism whereby bone resorption and deposition, necessary for orthodontic tooth movement, may be inhibited by prednisolone. However, at 12 days postappliance insertion. no difference in orthodontic tooth movement was observed following low-dose prednisolone treatment.
Keyword Bone
Corticosteroid
Resorption
Osteoblast like cells
Corticosteroid induced Osteoporosis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Dentistry Publications
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 14 Aug 2007, 16:00:39 EST