The sequence of a 200 kb portion of a Plasmodium vivax chromosome reveals a high degree of conservation with Plasmodium falciparum chromosome 3

Tchavtchitch, M., Fischer, K., Huestis, R. and Saul, A. (2001) The sequence of a 200 kb portion of a Plasmodium vivax chromosome reveals a high degree of conservation with Plasmodium falciparum chromosome 3. Molecular And Biochemical Parasitology, 118 2: 211-222. doi:10.1016/S0166-6851(01)00380-2


Author Tchavtchitch, M.
Fischer, K.
Huestis, R.
Saul, A.
Title The sequence of a 200 kb portion of a Plasmodium vivax chromosome reveals a high degree of conservation with Plasmodium falciparum chromosome 3
Journal name Molecular And Biochemical Parasitology   Check publisher's open access policy
ISSN 0166-6851
Publication date 2001
Sub-type Article (original research)
DOI 10.1016/S0166-6851(01)00380-2
Volume 118
Issue 2
Start page 211
End page 222
Total pages 12
Place of publication Amsterdam
Publisher Elsevier
Collection year 2001
Language eng
Subject C1
320299 Immunology not elsewhere classified
730102 Immune system and allergy
1108 Medical Microbiology
Abstract Within a 199 866 base pair (bp) portion of a Plasmodium vivax chromosome we identified a conserved linkage group consisting of at least 41 genes homologous to Plasmodium falciparum genes located on chromosome 3. There were no P. vivax homologues of the P. falciparum cytoadherence-linked asexual genes clag 3.2, clag 3.1 and a var C pseudogene found on the P. vivax chromosome. Within the conserved linkage group, the gene order and structure are identical to those of P. falciparum chromosome 3. This conserved linkage group may extend to as many as 190 genes. The subtelomeric regions are different in size and the P. vivax segment contains genes for which no P. falciparum homologues have been identified to date. The size difference of at least 900 kb between the homologous P. vivax chromosome and P. falciparum chromosome 3 is presumably due to a translocation. There is substantial sequence divergence with a much higher guanine + cytosine (G + C) content in the DNA and a preference for amino acids using GC-rich codons in the deduced proteins of P. vivax. This structural conservation of homologous genes and their products combined with sequence divergence at the nucleotide level makes the P. vivax genome a powerful tool for comparative analyses of Plasmodium genomes. (C) 2001 Elsevier Science B.V. All rights reserved.
Keyword Biochemistry & Molecular Biology
Parasitology
Plasmodium Vivax
Synteny
Chromosome
Conservation
Homology
Sequencing
Human Malaria Parasite
Genetic Diversity
Size Variation
Dna
Identification
Karyotype
Protein
Introns
Sites
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 14 Aug 2007, 15:59:10 EST