Effects of short-duration and long-duration exercise on lipoprotein(a)

Durstine, J. L., Davis, P. G., Ferguson, M. A., Alderson, N. L. and Trost, S. G. (2001) Effects of short-duration and long-duration exercise on lipoprotein(a). Medicine And Science In Sports And Exercise, 33 9: 1511-1516. doi:10.1097/00005768-200109000-00014


Author Durstine, J. L.
Davis, P. G.
Ferguson, M. A.
Alderson, N. L.
Trost, S. G.
Title Effects of short-duration and long-duration exercise on lipoprotein(a)
Journal name Medicine And Science In Sports And Exercise   Check publisher's open access policy
ISSN 0195-9131
Publication date 2001-09
Sub-type Article (original research)
DOI 10.1097/00005768-200109000-00014
Volume 33
Issue 9
Start page 1511
End page 1516
Total pages 6
Editor K.B. Pandolf
Place of publication Philadelphia, PA
Publisher Lippincott Williams & Wilkins
Collection year 2001
Language eng
Subject C1
321401 Exercise Physiology
730106 Cardiovascular system and diseases
1106 Human Movement and Sports Science
Abstract Purpose: Most studies that use either a single exercise session, exercise training, or a cross-sectional design have failed to find a relationship between exercise and plasma lipoprotein(a) [Lp(a)] concentrations. However, a few studies investigating the effects of longer and/or more strenuous exercise have shown elevated Lp(a) concentrations, possibly as an acute-phase reactant to muscle damage. Based on the assumption that greater muscle damage would occur with exercise of longer duration, the purpose of the present study was to determine whether exercise of longer duration would increase Lp(a) concentration and creatine kinase. (CK) activity more than exercise of shorter duration. Methods: Ten endurance-trained men (mean +/- SD: age, 27 +/- 6 yr; maximal oxygen consumption [(V)over dotO(2max)], 57 +/- 7 mL(.)kg(-1) min(-1)) completed two separate exercise sessions at 70% (V)over dotO(2max). One session required 900 kcal of energy expenditure (60 +/- 6 min), and the other required 1500 kcal (112 +/- 12 min). Fasted blood samples were taken immediately before (0-pre), immediately after (0-post), 1 d after (1-post), and 2 d after (2-post) each exercise session. Results: CK activity increased after both exercise sessions (mean +/- SE; 800 kcal: 0-pre 55 +/- 11, 1-post 168 +/- 64 U(.)L(-1.)min(-1); 1500 kcal: 0-pre 51 +/- 5, 1-post 187 +/- 30, 2-post 123 +/- 19 U(.)L(-1.)min(-1); P < 0.05). However, median Lp(a) concentrations were not altered by either exercise session (800 kcal: 0-pre 5.0 mg(.)dL(-1), 0-post 3.2 mg(.)dL(-1), 1-post 4.0 mg(.)dL(-1), 2-post 3.4 mg(.)dL(-1); 1500 kcal: 0-pre 5.8 mg(.)dL(-1), 0-post 4.3 mg(.)dL(-1), 1-post 3.2 mg(.)dL(-1), 2-post 5.3 mg(.)dL(-1)). In addition, no relationship existed between exercise-induced changes in CK activity and Lp(a) concentration (800 kcal: r = -0.26; 1500 kcal: r = -0.02). Conclusion: These results suggest that plasma Lp(a) concentration will not increase in response to minor exercise-induced muscle damage in endurance-trained runners.
Keyword Sport Sciences
Creatine Kinase
Muscle Damage
Elevated Serum Lipoprotein(a)
Physical-activity
Plasma Lipoprotein(a)
Eccentric Exercise
Sedentary Controls
Endothelial-cells
Sample Storage
Lp(a) Levels
Lipids
Fitness
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Human Movement and Nutrition Sciences Publications
 
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Created: Tue, 14 Aug 2007, 15:53:45 EST