ATM, a central controller of cellular responses to DNA damage

Khanna, KK, Lavin, MF, Jackson, SP and Mulhern, TD (2001) ATM, a central controller of cellular responses to DNA damage. Cell Death And Differentiation, 8 11: 1052-1065. doi:10.1038/sj.cdd.4400874


Author Khanna, KK
Lavin, MF
Jackson, SP
Mulhern, TD
Title ATM, a central controller of cellular responses to DNA damage
Journal name Cell Death And Differentiation   Check publisher's open access policy
ISSN 1350-9047
Publication date 2001-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/sj.cdd.4400874
Volume 8
Issue 11
Start page 1052
End page 1065
Total pages 14
Place of publication Basingstoke
Publisher Nature Publishing Group
Collection year 2001
Language eng
Subject C1
320305 Medical Biochemistry - Proteins and Peptides
730107 Inherited diseases (incl. gene therapy)
Abstract Mutations in the ATM gene lead to the genetic disorder ataxia-telangiectasia. ATM encodes a protein kinase that is mainly distributed in the nucleus of proliferating cells. Recent studies reveal that ATM regulates multiple cell cycle checkpoints by phosphorylating different targets at different stages of the cell cycle. ATM also functions in the regulation of DNA repair and apoptosis, suggesting that it is a central regulator of responses to DNA double-strand breaks.
Keyword Biochemistry & Molecular Biology
Cell Biology
Atm
P53
Brca1
Chk1
Chk2
Cell Cycle Checkpoints
Dna Repair
Apoptosis
Double-strand Breaks
Dependent Protein-kinase
Ataxia-telangiectasia Gene
Abl Tyrosine Kinase
Radiation-induced Apoptosis
Histone Acetylase Complex
Early Embryonic Lethality
Central-nervous-system
Ligase-iv Deficiency
Pik-related Kinases
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 01:53:01 EST