Genetics of cognition: Outline of a collaborative twin study

Wright, M. J., Eco, D., Ando, J, Luciano, M., Posthuma, D., Ono, Y., Hansell, N. K., Van Baal, C., Hiraishi, K., Hasegawa, T., Smith, G., Geffen, G. M., Geffen, L. B., Kanba, S., Miyake, A., Martin, N. G. and Boomsa, D. I. (2001) Genetics of cognition: Outline of a collaborative twin study. Twin Research, 4 1: 48-56.

Author Wright, M. J.
Eco, D.
Ando, J
Luciano, M.
Posthuma, D.
Ono, Y.
Hansell, N. K.
Van Baal, C.
Hiraishi, K.
Hasegawa, T.
Smith, G.
Geffen, G. M.
Geffen, L. B.
Kanba, S.
Miyake, A.
Martin, N. G.
Boomsa, D. I.
Title Genetics of cognition: Outline of a collaborative twin study
Journal name Twin Research   Check publisher's open access policy
ISSN 1369-0523
Publication date 2001
Sub-type Article (original research)
Volume 4
Issue 1
Start page 48
End page 56
Total pages 9
Editor N. Martin
Place of publication Australia
Publisher Australian Academic Press
Collection year 2001
Language eng
Subject C1
270210 Neurogenetics
380102 Learning, Memory, Cognition and Language
780108 Behavioural and cognitive sciences
Abstract Amultidisciplinary collaborative study examining cognition in a large sample of twins is outlined. A common experimental protocol and design is used in The Netherlands, Australia and Japan to measure cognitive ability using traditional IQ measures (i.e., psychometric IQ), processing speed (e.g., reaction time [RT] and inspection time [IT]), and working memory (e.g., spatial span, delayed response [DR] performance). The main aim is to investigate the genetic covariation among these cognitive phenotypes in order to use the correlated biological markers in future linkage and association analyses to detect quantitativetrait loci (QTLs). We outline the study and methodology, and report results from our preliminary analyses that examines the heritability of processing speed and working memory indices, and their phenotypic correlation with IQ. Heritability of Full Scale IQ was 87% in the Netherlands, 83% in Australia, and 71% in Japan. Heritability estimates for processing speed and working memory indices ranged from 33–64%. Associations of IQ with RT and IT (−0.28 to −0.36) replicated previous findings with those of higher cognitive ability showing faster speed of processing. Similarly, significant correlations were indicated between IQ and the spatial span working memory task (storage [0.31], executive processing [0.37]) and the DR working memory task (0.25), with those of higher cognitive ability showing better memory performance. These analyses establish the heritability of the processing speed and working memory measures to be used in our collaborative twin study of cognition, and support the findings that individual differences in processing speed and working memory may underlie individual differences in psychometric IQ.
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
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Created: Tue, 14 Aug 2007, 15:51:41 EST