A novel method for solid-phase synthesis of oligosaccharides using the N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) linker

Drinnan, Nicholas, West, Michael L., Broadhurst, Max, Kellam, Barrie and Toth, Istvan (2001) A novel method for solid-phase synthesis of oligosaccharides using the N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) linker. Tetrahedron Letters, 42 6: 1159-1162. doi:10.1016/S0040-4039(00)02197-3


Author Drinnan, Nicholas
West, Michael L.
Broadhurst, Max
Kellam, Barrie
Toth, Istvan
Title A novel method for solid-phase synthesis of oligosaccharides using the N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) linker
Journal name Tetrahedron Letters   Check publisher's open access policy
ISSN 0040-4039
Publication date 2001-02-05
Sub-type Article (original research)
DOI 10.1016/S0040-4039(00)02197-3
Open Access Status
Volume 42
Issue 6
Start page 1159
End page 1162
Total pages 4
Place of publication Oxford
Publisher Pergamon Press
Collection year 2001
Language eng
Subject C1
320501 Pharmaceutical Sciences and Pharmacy
670403 Treatments (e.g. chemicals, antibiotics)
Abstract The application of the N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) linker for the solid-phase synthesis of oligosaccharides is described. The oligosaccharide products can be cleaved from the resin by hydrazine, ammonia or primary amines, but the linker is stable under the conditions of oligosaccharide synthesis. The first sugar can be attached to the resin linker via a vinylogous amide bond, or by ether linkage using a p-aminobenzyl alcohol converter. (C) 2001 Elsevier Science Ltd. All rights reserved.
Keyword Chemistry, Organic
Solid-phase/Oligosaccharide Synthesis
Dimedone Based Linker
Carbohydrate Library
Polymer
Glycosylation
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Tue, 14 Aug 2007, 15:46:22 EST