Phasic modulation of corticomotor excitability during passive movement of the upper limb: effects of movement frequency and muscle specificity

Lewis, G. N., Byblow, W. D. and Carson, R. G. (2001) Phasic modulation of corticomotor excitability during passive movement of the upper limb: effects of movement frequency and muscle specificity. Brain Research, 900 2: 282-294. doi:10.1016/S0006-8993(01)02369-1


Author Lewis, G. N.
Byblow, W. D.
Carson, R. G.
Title Phasic modulation of corticomotor excitability during passive movement of the upper limb: effects of movement frequency and muscle specificity
Journal name Brain Research   Check publisher's open access policy
ISSN 0006-8993
1872-6240
Publication date 2001
Sub-type Article (original research)
DOI 10.1016/S0006-8993(01)02369-1
Volume 900
Issue 2
Start page 282
End page 294
Total pages 13
Place of publication Amsterdam
Publisher Elsevier
Collection year 2001
Language eng
Subject C1
321403 Motor Control
730104 Nervous system and disorders
1109 Neurosciences
1702 Cognitive Sciences
Abstract Modulations in the excitability of spinal reflex pathways during passive rhythmic movements of the lower limb have been demonstrated by a number of previous studies [4]. Less emphasis has been placed on the role of supraspinal pathways during passive movement, and on tasks involving the upper limb. In the present study, transcranial magnetic stimulation (TMS) was delivered to subjects while undergoing passive flexion-extension movements of the contralateral wrist. Motor evoked potentials (MEPs) of flexor carpi radialis (FCR) and abductor pollicus brevis (APB) muscles were recorded. Stimuli were delivered in eight phases of the movement cycle during three different frequencies of movement. Evidence of marked modulations in pathway excitability was found in the MEP amplitudes of the FCR muscle, with responses inhibited and facilitated from static values in the extension and flexion phases, respectively. The results indicated that at higher frequencies of movement there was greater modulation in pathway excitability. Paired-pulse TMS (sub-threshold conditioning) at short interstimulus intervals revealed modulations in the extent of inhibition in MEP amplitude at high movement frequencies. In the APE muscle, there was some evidence of phasic modulations of response amplitude, although the effects were less marked than those observed in FCR. It is speculated that these modulatory effects are mediated via Ia afferent pathways and arise as a consequence of the induced forearm muscle shortening and lengthening. Although the level at which this input influences the corticomotoneuronal pathway is difficult to discern, a contribution from cortical regions is suggested. (C) 2001 Published by Elsevier Science B.V.
Keyword Neurosciences
Transcranial Magnetic Stimulation
Passive Movement
Corticospinal Pathway
Ia Afferent
Intracortical Inhibition
Human Motor Cortex
H-reflex Modulation
Corticocortical Inhibition
Magnetic Stimulation
Corticospinal Input
Human Hand
Responses
Reorganization
Mechanisms
Stretch
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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