Distribution of C-14 Cylindrospermopsin in vivo in the mouse

Norris, RLG, Seawright, AA, Shaw, GR, Smith, MJ, Chiswell, RK and Moore, MR (2001) Distribution of C-14 Cylindrospermopsin in vivo in the mouse. Environmental Toxicology, 16 6: 498-505. doi:10.1002/tox.10008

Author Norris, RLG
Seawright, AA
Shaw, GR
Smith, MJ
Chiswell, RK
Moore, MR
Title Distribution of C-14 Cylindrospermopsin in vivo in the mouse
Journal name Environmental Toxicology   Check publisher's open access policy
ISSN 1520-4081
Publication date 2001
Sub-type Article (original research)
DOI 10.1002/tox.10008
Volume 16
Issue 6
Start page 498
End page 505
Total pages 8
Place of publication New York
Publisher John Wiley & Sons Inc
Collection year 2001
Language eng
Subject C1
730210 Environmental health
321299 Public Health and Health Services not elsewhere classified
Abstract Radiolabelled C-14 cylindrospermopsin (CYN) has been prepared and used to investigate the distribution and excretion of CYN in vivo in male Quackenbush mice. At a dose of 0.2 mg/kg (i.e., approx. median lethal dose) the following mean (SID) urinary and faecal recoveries (cumulative) were obtained, respectively: (0-6 hours, n = 4) 48.2 (29.3)%, 11.9 (21.4)%; (0-12 hours, n = 12) 66.0 (27.1)%, 5.7 (5.6)%; (0-24 hours, n = 12) 68.4 (26.7)%, 8.5 (8.1)%. Mean (SD) recoveries from livers at 6 hours were 20.6 (6.4)% (n = 4), at 48 hours 13.1 (7.7)% (n = 8), and 5-7 days were 2.1 (2.1)% (n = 8). A substantial amount (up to 23%) can be retained in the liver for up to 48 hours with a lesser amount retained in the kidneys. The excretion patterns show substantial interindividual variability between predominantly faecal or urinary excretion, but these patterns are not related in any simple manner to the outcome in terms of toxicity. There is at least one methanol-extractable metabolite as well as a nonmethanol-extractable metabolite in the liver. The methanol-extractable metabolite was not found in the kidney and is more hydrophilic than CYN itself on reverse phase. (C) 2001 by John Wiley & Sons, Inc.
Keyword Environmental Sciences
Water Resources
Distribution Elimination
Cylindrospermopsin Mouse
Cyanobacterial Alkaloid Cylindrospermopsin
Alga Microcystis-aeruginosa
Cultured Rat Hepatocytes
Raciborskii Woloszynska
Tissue Distribution
Umezakia Natans
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
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Citation counts: TR Web of Science Citation Count  Cited 41 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 14 Aug 2007, 15:45:35 EST