Application of DNA microarrays to study human alcoholism

Lewohl, Jo M., Dodd, Peter R., Mayfield, R. Dayne and Harris, R. Adron (2001) Application of DNA microarrays to study human alcoholism. Journal of Biomedical Science, 8 1: 28-36.


Author Lewohl, Jo M.
Dodd, Peter R.
Mayfield, R. Dayne
Harris, R. Adron
Title Application of DNA microarrays to study human alcoholism
Journal name Journal of Biomedical Science   Check publisher's open access policy
ISSN 1021-7770
Publication date 2001-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/BF02255968
Volume 8
Issue 1
Start page 28
End page 36
Total pages 9
Place of publication Basel, Switzerland
Publisher Karger
Collection year 2001
Language eng
Subject C1
270107 Cell Neurochemistry
270201 Gene Expression
320702 Central Nervous System
321020 Pathology
730104 Nervous system and disorders
730205 Substance abuse
Abstract An emerging idea is that long-term alcohol abuse results in changes in gene expression in the brain and that these changes are responsible at least partly for alcohol tolerance, dependence and neurotoxicity, The overall goal of our research is to identify genes which are differentia[ly expressed in the brains of well-characterized human alcoholics as compared with non-alcoholics. This should identify as-yet-unknown alcohol-responsive genes, and may well confirm changes in the expression of genes which have been delineated in animal models of alcohol abuse. Cases were carefully selected and samples pooled on the basis of relevant criteria; differential expression was monitored by microarray hybridization. The inherent diversity of human alcoholics can be exploited to identify genes associated with specific pathological processes, as well as to assess the effects of concomitant disease, severity of brain damage, drinking behavior, and factors such as gender and smoking history. initial results show selective changes in gene expression in alcoholics; of particular importance is a coordinated reduction in genes coding for myelin components, Copyright (C) 2001 National Science Council, ROC and S. Karger AG, Basel.
Keyword Medicine, Research & Experimental
Gene Expression
Gene Chip
Myelin
Frontal Cortex
Central-nervous-system
Drug-addiction
Rat-brain
Differential Display
Gene-expression
Multiple-sclerosis
Ethanol-metabolism
Growth-factors
Delta-fosb
Receptor
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Tue, 14 Aug 2007, 15:35:11 EST